Synthesis, antibacterial evaluation and molecular docking studies of novel series of acridone- 1,2,3-triazole derivatives

Development of new drugs with antibacterial potency is an important solution to overcome drug-resistance problems. In the goal to develop novel structure with antibacterial potency, we designed and synthesized novel acridone derivatives bearing triazole nucleus. The novel synthesized compounds were...

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Bibliographic Details
Published in:Structural chemistry 2020-08, Vol.31 (4), p.1523-1531
Main Authors: Aarjane, Mohammed, Slassi, Siham, Tazi, Bouchra, Maouloua, Mohamed, Amine, Amina
Format: Article
Language:English
Subjects:
Antibacterial materials
Chemical synthesis
Chemistry
Chemistry and Materials Science
Computer Applications in Chemistry
Derivatives
Molecular docking
Original Research
Physical Chemistry
Theoretical and Computational Chemistry
Triazoles
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Summary:Development of new drugs with antibacterial potency is an important solution to overcome drug-resistance problems. In the goal to develop novel structure with antibacterial potency, we designed and synthesized novel acridone derivatives bearing triazole nucleus. The novel synthesized compounds were tested for their in vitro antibacterial activity against four bacterial human pathogenic strains. The compound 4h displayed significant antibacterial activities against Staphylcoccus aureus (MRSA) with MIC = 19.6 μg/mL. The synthesized compounds were subjected for docking study to understand the interaction of our compounds and the dihydropteroate synthase (DHPS) in methicillin-resistant Staphylcoccus aureus (MRSA).
ISSN:1040-0400
1572-9001
DOI:10.1007/s11224-020-01512-0