Aggregation and Crosslinking of Poly(N,N‐dimethylacrylamide)‐b‐pullulan Double Hydrophilic Block Copolymers

The self‐assembly of polymers is a major topic in current polymer chemistry. In here, the self‐assembly of a pullulan based double hydrophilic block copolymer, namely pullulan‐b‐poly(N,N‐dimethylacrylamide)‐co‐poly(diacetone acrylamide) (Pull‐b‐(PDMA‐co‐PDAAM)) is described. The hydrophilic block co...

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Bibliographic Details
Published in:Macromolecular chemistry and physics 2020-07, Vol.221 (13), p.n/a
Main Authors: Plucinski, Alexander, Willersinn, Jochen, Lira, Rafael B., Dimova, Rumiana, Schmidt, Bernhard V. K. J.
Format: Article
Language:English
Subjects:
Acrylamide
Aggregates
Aqueous solutions
Assembly
Biomedical materials
biopolymers
Block copolymers
Crosslinking
Dilution
Hydrophilicity
Phase separation
Polymer chemistry
Pullulan
reversible addition fragmentation chain transfer (RAFT)
self‐assembly
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Summary:The self‐assembly of polymers is a major topic in current polymer chemistry. In here, the self‐assembly of a pullulan based double hydrophilic block copolymer, namely pullulan‐b‐poly(N,N‐dimethylacrylamide)‐co‐poly(diacetone acrylamide) (Pull‐b‐(PDMA‐co‐PDAAM)) is described. The hydrophilic block copolymer induces phase separation at high concentration in aqueous solution. Additionally, the block copolymer displays aggregates at lower concentration, which show a size dependence on concentration. In order to stabilize the aggregates, crosslinking via oxime formation is described, which enables preservation of aggregates at high dilution, in dialysis and in organic solvents. With adequate stability by crosslinking, double hydrophilic block copolymer (DHBC) aggregates open pathways for potential biomedical applications in the future. The double hydrophilic block copolymer poly(N,N‐dimethylacrylamide)‐b‐pullulan shows an unique aggregation behavior in aqueous solution at concentrations above 20 wt% leading to a polymer rich and a polymer depleted phase. At this concentration crosslinking is performed to synthesize hydrophilic particles in the size range of 30 nm to 1 µm that are stable at low concentration and in organic solvent.
ISSN:1022-1352
1521-3935
DOI:10.1002/macp.202000053