Recent Advances in Alkyne Hydroamination as a Powerful Tool for the Construction of C−N Bonds

• Published in: Asian journal of organic chemistry 2020-07, Vol.9 (7), p.969-991
• Main Authors: Tashrifi, Zahra, Mohammadi Khanaposhtani, Mohammad, Biglar, Mahmood, Larijani, Bagher, Mahdavi, Mohammad
• Format: Article
• Language: English
• Subjects: alkyne; Alkynes; cyclization; C−N bonds; hydroamination; N-heterocycles; Organic chemistry; Reaction mechanisms; Researchers
• ISSN: 2193-5807; 2193-5815
• DOI: 10.1002/ajoc.202000092

Alkyne hydroamination reaction has attracted many researchers due to its capability to form the required C−N bonds in the synthesis of the biologically and pharmacologically active N‐heterocycles. Hence, in this review, a comprehensive and updated summary of the research progress in this area (from 2014 on) is presented. In order to provide an easier access to the required information, a brief and concise description of the reaction mechanisms and preparation of precursors is also included, where possible. Accordingly, the alkyne hydroamination reactions are classified and summarized based on the type of hydroamination (inter‐ or intramolecular) and each class is further subdivided according to the number of members in the rings, so as to help the researchers in designing new N‐hetrocycles. In this review, the latest research carried out in the field of alkyne hydroamination reactions was classified into three main categories: intermolecular, intramolecular and both inter/intramolecular hydroamination. The intermolecular hydroamination could be further subdivided into cyclization and side chaining but the intramolecular hydroamination is solely realized through cyclization. The cyclization in each of the major hydroamination categories can, in turn, be classified based on the number of members of the rings formed as offered in the present article.