Electrochemical dehydrogenative cross-coupling of xanthenes with ketones

A new external oxidant-free electrochemical dehydrogenative cross-coupling of xanthenes and ketones for the preparation of functionalized 9-alkyl-9 H -xanthenes was developed. This method enables the formation of a new C(sp 3 )-C(sp 3 ) bond through release of H 2 as the major byproduct at room temp...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-07, Vol.56 (55), p.7585-7588
Main Authors: Yang, Yong-Zheng, Wu, Yan-Chen, Song, Ren-Jie, Li, Jin-Heng
Format: Article
Language:English
Subjects:
Cross coupling
Dehydrogenation
Ketones
Oxidizing agents
Room temperature
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Summary:A new external oxidant-free electrochemical dehydrogenative cross-coupling of xanthenes and ketones for the preparation of functionalized 9-alkyl-9 H -xanthenes was developed. This method enables the formation of a new C(sp 3 )-C(sp 3 ) bond through release of H 2 as the major byproduct at room temperature, and features mild conditions, high atom economy, excellent functional-group tolerance, scalability and facile applications in pharmaceutical chemistry. An oxidant-free electrochemical dehydrogenative cross-coupling of xanthenes and ketones for the preparation of functionalized 9-alkyl-9 H -xanthenes was developed.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc02580a