Characterization of biodegradable poly(l‐lactide) tube over accelerated degradation

The next‐generation bioresorbable polymeric stents are undergoing continual research and development, especially how to control and optimize their degradation behaviors. The aim of this paper is to study the properties of a poly(l‐lactide) (PLLA) tube over accelerated degradation in vitro. Spherical...

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Bibliographic Details
Published in:Polymer engineering and science 2020-07, Vol.60 (7), p.1430-1436
Main Authors: Naseem, Raasti, Zhao, Liguo, Eswaran, Senthil K., Willcock, Helen
Format: Article
Language:English
Subjects:
Biocompatibility
Biodegradability
biodegradable polymeric stents
Biomedical materials
Calorimetry
Degradation
differential scanning calorimetry
gel permeation chromatography
Liquid chromatography
Mechanical properties
Nanoindentation
Polylactic acid
R&D
Research & development
spherical nanoindentation
Stents
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Summary:The next‐generation bioresorbable polymeric stents are undergoing continual research and development, especially how to control and optimize their degradation behaviors. The aim of this paper is to study the properties of a poly(l‐lactide) (PLLA) tube over accelerated degradation in vitro. Spherical nanoindentation was particularly adopted to measure the mechanical properties of PLLA tube; while differential scanning calorimetry and gel permeation chromatography were used for crystallinity and molecular weight measurements. Overall, the material degradation was captured by the local stress‐strain response obtained with spherical nanoindentation, and further confirmed with chemical analyses. The results are particularly useful for development of bioresorbable polymeric stents with improved performance.
ISSN:0032-3888
1548-2634
DOI:10.1002/pen.25390