Selective serotonin reuptake inhibitor use during pregnancy and possible neonatal complications

This paper reviews the risks and benefits of using selective serotonin reuptake inhibitors (SSRIs) in pregnant women. The effects of SSRI use on pregnant women and fetuses are discussed, and the need for SSRI treatment is explained. Persistent pulmonary hypertension of the newborn, teratogenic risks...

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Bibliographic Details
Published in:Current psychiatry reports 2009-06, Vol.11 (3), p.253-257
Main Authors: Sackett, Jillan Cantor, Weller, Ronald A., Weller, Elizabeth B.
Format: Article
Language:English
Subjects:
Abnormalities, Drug-Induced - etiology
Antidepressants
Depressive Disorder - drug therapy
Female
Humans
Maternal-Fetal Exchange
Medicine
Medicine & Public Health
Neonatal care
Pregnancy
Pregnancy Complications - drug therapy
Psychiatry
Risk Factors
Serotonin
Serotonin Uptake Inhibitors - adverse effects
Serotonin Uptake Inhibitors - therapeutic use
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Summary:This paper reviews the risks and benefits of using selective serotonin reuptake inhibitors (SSRIs) in pregnant women. The effects of SSRI use on pregnant women and fetuses are discussed, and the need for SSRI treatment is explained. Persistent pulmonary hypertension of the newborn, teratogenic risks of SSRI treatment during pregnancy, neonatal adaptations, and long-term outcomes for children whose mothers used SSRIs during pregnancy are specifically considered. Due to conflicting results from current studies, there are no clear guidelines for SSRI treatment in pregnancy. Patients and doctors must discuss together the risks and benefits of SSRI use during pregnancy and decide on a course of treatment. Potential risks must be balanced against the effects of untreated maternal depression.
ISSN:1523-3812
1535-1645
DOI:10.1007/s11920-009-0038-5