Photodynamic treatment of melanoma cells using aza-dipyrromethenes as photosensitizers

In this study, we report for the first time the use of four aza-dipyrromethenes (ADPMs) as photosensitizers for cancer PDT. The synthesis and characterization of the ADPMs and their photodynamic action against B16F10 melanoma cells were assessed. ADPM 2 is the best singlet oxygen generator and the m...

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Bibliographic Details
Published in:Photochemical & photobiological sciences 2020-07, Vol.19 (7), p.885-891
Main Authors: Castro, Kelly A. D. F, Costa, Letícia D, Guieu, Samuel, Biazzotto, Juliana C, Neves, Maria da Graça P. M. S, Faustino, M. Amparo F, da Silva, Roberto, Tomé, Augusto C
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Aza Compounds - chemical synthesis
Aza Compounds - chemistry
Aza Compounds - pharmacology
Biochemistry
Biomaterials
Cell Proliferation - drug effects
Cell Survival - drug effects
Chemistry
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Melanoma
Melanoma - drug therapy
Melanoma - pathology
Mice
Molecular Structure
Photochemotherapy
Photosensitizing Agents - chemical synthesis
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
Physical Chemistry
Plant Sciences
Porphobilinogen - analogs & derivatives
Porphobilinogen - chemical synthesis
Porphobilinogen - chemistry
Porphobilinogen - pharmacology
Singlet oxygen
Structure-Activity Relationship
Tumor Cells, Cultured
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Summary:In this study, we report for the first time the use of four aza-dipyrromethenes (ADPMs) as photosensitizers for cancer PDT. The synthesis and characterization of the ADPMs and their photodynamic action against B16F10 melanoma cells were assessed. ADPM 2 is the best singlet oxygen generator and the most phototoxic (at 2.5 μM) towards B16F10 cells. In this study, we report for the first time the use of four aza-dipyrromethenes (ADPMs) as photosensitizers for cancer PDT.
ISSN:1474-905X
1474-9092
DOI:10.1039/d0pp00114g