Radiation Synthesis of Magnesium Doped Nano Hydroxyapatite/(Acacia-Gelatin) Scaffold for Bone Tissue Regeneration: In Vitro Drug Release Study

Novel three-dimensional biodegradable porous nanocomposite bone scaffolds were fabricated using acacia gum and gelatin as the base polymer matrix and magnesium doped nano hydroxyapatite as cementing materials using gamma irradiation facility for crosslinking and sterilization processes. Mg-doped HAp...

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Bibliographic Details
Published in:Journal of inorganic and organometallic polymers and materials 2020-08, Vol.30 (8), p.2890-2906
Main Authors: Raafat, Amany I., Kamal, H., Sharada, Hayat M., Abd elhalim, Sawsan A., Mohamed, Randa D.
Format: Article
Language:English
Subjects:
Apatite
Biocompatibility
Biodegradability
Biomedical materials
Cementing
Chemical synthesis
Chemistry
Chemistry and Materials Science
Crosslinking
Drug delivery systems
E coli
Functional groups
Gamma irradiation
Gamma rays
Gelatin
Hydroxyapatite
Inorganic Chemistry
Ketoprofen
Magnesium
Mechanical properties
Nanocomposites
Nanoparticles
Organic Chemistry
Polymer Sciences
Porosity
Regeneration
Scaffolds
Sterilization
Tissue engineering
Toxicity
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Summary:Novel three-dimensional biodegradable porous nanocomposite bone scaffolds were fabricated using acacia gum and gelatin as the base polymer matrix and magnesium doped nano hydroxyapatite as cementing materials using gamma irradiation facility for crosslinking and sterilization processes. Mg-doped HAp nanoparticles were synthesized using wet chemical method. XRD studies verified the nano-scale size of the prepared HAp. In addition to Ca and P in the prepared n-HAp, the EDX analysis revealed the presence of Mg in the doped HAp samples. FTIR studies confirmed the existence of the characteristic functional groups of the scaffold constituents. The swelling behavior was found to be dependent on the quantity of embedded HAp nanoparticles. Nanocomposite scaffold porosity ranged from 26 to 39%, which increased with the inclusion of Mg ions. The developed scaffolds showed appropriate mechanical properties that enhanced by the existence of HAp nanoparticles. The incorporation of the Mg-doped HAp nanoparticles encourages the development of bone-like apatite layer. In vitro cytotoxicity assessment and blood compatibility demonstrated their biocompatibility. The developed scaffolds show promising antibacterial activity against Staphylococcus aureus and Escherichia coli. In vitro drug release study showed that the loaded Ketoprofen scaffolds were able to deliver the loaded drug sustainably.
ISSN:1574-1443
1574-1451
DOI:10.1007/s10904-019-01418-3