An Easy Access to Oxime Ethers by Pd‐Catalyzed C—O Cross‐Coupling of Activated Aryl Bromides with Ketoximes and Chalcone Oximes

Summary of main observation and conclusion An efficient Pd‐catalyzed method for C—O cross‐coupling of ketoximes and chalcone oximes with activated aryl bromides and bromo‐chalcones has been developed. All oxime ethers were obtained in good to excellent yields by [(π‐allyl)PdCl]2/tBuXPhos (L7) cataly...

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Bibliographic Details
Published in:Chinese journal of chemistry 2020-08, Vol.38 (8), p.830-836
Main Authors: Reeta, Rangarajan, T. M., Singh, Raj Pal, Singh, R. P., Singh, Manjula
Format: Article
Language:English
Subjects:
Aromatic compounds
Bromides
Catalysts
Chalcone oxime ethers
Cross coupling
Ethers
Ketoxime ethers
Oximes
Palladium
Synthetic methods
tBuXPhos
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Summary:Summary of main observation and conclusion An efficient Pd‐catalyzed method for C—O cross‐coupling of ketoximes and chalcone oximes with activated aryl bromides and bromo‐chalcones has been developed. All oxime ethers were obtained in good to excellent yields by [(π‐allyl)PdCl]2/tBuXPhos (L7) catalyst system. TrixiePhos (L11) was also found to be effective for the oxime coupling. This method offers an easy and smooth coupling of chalcone oximes with activated aryl bromides and bromo‐chalcones, which has not been previously explored.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201900540