Genetically Encoded Click Chemistry

Genetically encoded click chemistry (GECC) refers to a category of peptide/protein reactions that can spontaneously form covalent linkages with high efficiency and selectivity under mild physiological conditions. The emergence of powerful SpyTag/SpyCatcher chemistry, a prototype of GECC, has opened...

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Bibliographic Details
Published in:Chinese journal of chemistry 2020-08, Vol.38 (8), p.894-896
Main Authors: Sun, Fei, Zhang, Wen‐Bin
Format: Article
Language:English
Subjects:
Chemical reactions
Chemical synthesis
Chemistry
Click chemistry
Genetic code
Materials science
Organelles
Protein engineering
Proteins
Selectivity
SpyCatcher
SpyTag
Synthetic biology
Topology
Topology engineering
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Summary:Genetically encoded click chemistry (GECC) refers to a category of peptide/protein reactions that can spontaneously form covalent linkages with high efficiency and selectivity under mild physiological conditions. The emergence of powerful SpyTag/SpyCatcher chemistry, a prototype of GECC, has opened the door to new fields such as in cellulo protein topology engineering and design of synthetic organelles. The continuing developments of GECC will surely provide great opportunities for future materials science and synthetic biology and open up a new avenue to information‐coded chemical reactions. As demonstrated in the prototypical SpyTag‐SpyCatcher reaction, genetically encoded click chemistry is a superior way to manipulate chemical reactivity and holds great promise in diverse applications.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.202000101