Synthesis, Structure, and Cytotoxicity of Pd(II) and Cu(II) Complexes with 1-Terpenyl-3-Thiosemicarbazides of Pinane and para-Menthane Series

• Published in: Journal of structural chemistry 2020, Vol.61 (1), p.44-56
• Main Authors: Kokina, T. E., Komarov, V. Yu, Glinskaya, L. A., Bizyaev, S. N., Sheludyakova, L. A., Eremina, Yu. A., Klyushova, L. S., Tkachev, A. V.
• Format: Article
• Language: English
• Subjects: Atomic; Atomic/Molecular Structure and Spectra; Chemistry; Chemistry and Materials Science; Coordination compounds; Crystal structure; Crystals; Cytotoxicity; Hydrochlorination; Infrared spectroscopy; Inorganic Chemistry; Larynx; Ligands; Molecular; Optical and Plasma Physics; Physical Chemistry; Single crystals; Solid State Physics; Thiosemicarbazides; Toxicity
• ISSN: 0022-4766; 1573-8779
• DOI: 10.1134/S0022476620010059

PdL 1,2 Cl 2 ·H 2 O ( I, II ) and CuL 1 Cl 2 ·H 2 O ( III ) complexes (L 1 and L 2 are 1-terpenyl-3-thiosemicarbazides of pinane and para -menthane series, respectively) are obtained. Single crystals of complexes I and [PdL 3 Cl 2 ] ( IV ) (L 3 is the product of hydrochlorination of ligand L 2 ) have been grown. According to XRD data, crystal structures of I, IV consist of complex cations [PdLCl] + and outer-sphere anions Cl − . The coordination polyhedron N 2 SCl is a distorted square. L 1 and L 3 are tridentate ligands. Free ligands L 1 , L 2 and complexes I-III are studied using IR spectroscopy; conclusions on the structure of the Cu(II) complex are inferred from the analysis of obtained data. Cytotoxic properties of L 1 , complexes I and III , as well as the carboplatin pharmaceutic are studied on the Hep2 (human larynx carcinoma) cell line. Complexes I and III are shown to be moderately cytotoxic: they are twice as less toxic with respect to Hep2 cells than carboplatin that is used in the experiment as the reference complex.