Self-assembly and hydrogel formation ability of Fmoc-dipeptides comprising α-methyl-L-phenylalanine

Various biofunctional hydrogel materials can be fabricated in aqueous media through the self-assembly of peptide derivatives, forming supramolecular nanostructures and their three-dimensional networks. In this study, we describe the self-assembly of new Fmoc-dipeptides comprising α-methyl-L-phenylal...

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Published in:Polymer journal 2020-08, Vol.52 (8), p.923-930
Main Authors: Arakawa, Hanae, Takeda, Kumi, Higashi, Sayuri L., Shibata, Aya, Kitamura, Yoshiaki, Ikeda, Masato
Format: Article
Language:English
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639/301/54
639/638/541
Aqueous solutions
Biomaterials
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Hydrogels
Morphology
Nanostructure
Original Article
Phenylalanine
Polymer Sciences
Self-assembly
Surfaces and Interfaces
Thin Films
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cited_by cdi_FETCH-LOGICAL-c359t-41302109457f0ff8eead9c3587301b66e15b7b46a0a5c19b2d2f3422155b78b3
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container_title Polymer journal
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creator Arakawa, Hanae
Takeda, Kumi
Higashi, Sayuri L.
Shibata, Aya
Kitamura, Yoshiaki
Ikeda, Masato
description Various biofunctional hydrogel materials can be fabricated in aqueous media through the self-assembly of peptide derivatives, forming supramolecular nanostructures and their three-dimensional networks. In this study, we describe the self-assembly of new Fmoc-dipeptides comprising α-methyl-L-phenylalanine. We found that the position and number of methyl groups introduced onto the α carbons of the Fmoc-dipeptides by α-methyl-L-phenylalanine have a marked influence on the morphology of the supramolecular nanostructure as well as the hydrogel (network) formation ability. This article describes the self-assembly of Fmoc-dipeptides comprising α-methyl-L-phenylalanine. The position and number of methyl groups introduced onto the α carbons of the Fmoc-dipeptides as α-methyl-L-phenylalanine have a marked influence on the morphology of supramolecular nanostructures and the hydrogel formation ability.
doi_str_mv 10.1038/s41428-019-0301-5
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subjects 639/301/54
639/638/541
Aqueous solutions
Biomaterials
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Hydrogels
Morphology
Nanostructure
Original Article
Phenylalanine
Polymer Sciences
Self-assembly
Surfaces and Interfaces
Thin Films
title Self-assembly and hydrogel formation ability of Fmoc-dipeptides comprising α-methyl-L-phenylalanine
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