A validation study of manual atrophy measures in patients with Multiple Sclerosis

Purpose Manual measures such as corpus callosum index, normalized corpus callosum area, and width of the third ventricle are potential biomarkers for brain atrophy. In this work, we investigate their suitability to assess the neurodegenerative component of multiple sclerosis (MS) by comparing them t...

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Bibliographic Details
Published in:Neuroradiology 2020-08, Vol.62 (8), p.955-964
Main Authors: Cappelle, Sarah, Pareto, Deborah, Tintoré, Mar, Vidal-Jordana, Angela, Alyafeai, Rumaiza, Alberich, Manel, Sastre-Garriga, Jaume, Auger, Cristina, Montalban, Xavier, Rovira, Àlex
Format: Article
Language:English
Subjects:
Adult
Atrophy
Atrophy - pathology
Biomarkers
Brain
Cerebral Ventricles - diagnostic imaging
Cerebral Ventricles - pathology
Corpus callosum
Corpus Callosum - diagnostic imaging
Corpus Callosum - pathology
Correlation analysis
Diagnostic Neuroradiology
Disability Evaluation
Female
Humans
Imaging
Immunologic Factors - therapeutic use
Interferon
Interferon-beta - therapeutic use
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medicine
Medicine & Public Health
Monoclonal antibodies
Multiple sclerosis
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - drug therapy
Multiple Sclerosis - pathology
Natalizumab - therapeutic use
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Organ Size
Radiology
Statistical analysis
Ventricle
Ventricles (cerebral)
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Summary:Purpose Manual measures such as corpus callosum index, normalized corpus callosum area, and width of the third ventricle are potential biomarkers for brain atrophy. In this work, we investigate their suitability to assess the neurodegenerative component of multiple sclerosis (MS) by comparing them to volumetric measures and expanded disability status scale (EDSS). Methods Fifty-eight patients with a clinically isolated syndrome, 48 MS patients treated with interferon β, and 26 treated with natalizumab underwent a brain MRI at baseline and after 1 year. Manual measures were evaluated by two observers using Jim v.6.0 at both time points. Volumetric tools (SIENA/x and Freesurfer) were used to calculate normalized brain volume, brain parenchymal fraction, annualized percentage of brain volume change, corpus callosum volume, ventricle volume, and volume of the third ventricle. Statistical analyses were performed with SPSS v.13. Results Usage of corpus callosum volume and third ventricle volume to validate normalized corpus callosum area and width of the third ventricle, respectively, showed very good correlations ( r  = 0.85, r  = 0.83; p  
ISSN:0028-3940
1432-1920
DOI:10.1007/s00234-020-02401-3