Effects of the hallucinogenic beverage ayahuasca on voluntary ethanol intake by rats and on cFos expression in brain areas relevant to drug addiction

Ayahuasca is a hallucinogenic infusion used in religious rituals that has serotoninergic properties and may be a potential therapeutic option for drug addiction. In this study, Wistar rats had intermittent access to ethanol for 8 weeks, receiving water (control), naltrexone (NTX, 2 mg/kg body weight...

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Bibliographic Details
Published in:Alcohol (Fayetteville, N.Y.) N.Y.), 2020-05, Vol.84, p.67-75
Main Authors: Nolli, Luciana Marangni, de Oliveira, Danilo Gustavo Rodrigues, Alves, Stefany Sousa, von Zuben, Marcus Vinicius, Pic-Taylor, Aline, Mortari, Marcia Renata, Caldas, Eloisa Dutra
Format: Article
Language:English
Subjects:
Addictions
Alcohol
Alcohol Drinking
Alcohol use
Animals
ayahuasca
Banisteriopsis
Beverages
Blood
Body weight
Brain - drug effects
Brain research
cFos protein
Corpus Striatum - drug effects
Cortex
Dopamine receptors
Drug addiction
Drug dosages
Ethanol
Ethanol - administration & dosage
Hallucinogens
Hallucinogens - pharmacology
Hemoglobin
Laboratory animals
Male
Models, Animal
Naltrexone
Naltrexone - pharmacology
Narcotic Antagonists - pharmacology
Neostriatum
Nucleus accumbens
Nucleus Accumbens - drug effects
Prefrontal Cortex - drug effects
Proto-Oncogene Proteins c-fos - metabolism
Psychedelic drugs
Psychotropic drugs
Rats
Rats, Wistar
Serotonin
Water - administration & dosage
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Summary:Ayahuasca is a hallucinogenic infusion used in religious rituals that has serotoninergic properties and may be a potential therapeutic option for drug addiction. In this study, Wistar rats had intermittent access to ethanol for 8 weeks, receiving water (control), naltrexone (NTX, 2 mg/kg body weight [bw] intraperitoneally [i.p.]) or ayahuasca (Aya) at 0.5x, 1x, or 2x the ritual dose in the final 5 days. A naïve group had access only to water. Ethanol intake was estimated throughout the experiment, and cFos expression was evaluated in medial orbital cortex (MO), ventral orbital cortex (VO), lateral orbital cortex (LO), nucleus accumbens (NAc), and striatum. Treatment with either NTX or Aya (oral) did not decrease ethanol intake compared to the baseline level (5th to 7th week), but the NTX group intake was significantly lower than controls (p 
ISSN:0741-8329
1873-6823
DOI:10.1016/j.alcohol.2019.10.005