Rapid Decay of Anti–SARS-CoV-2 Antibodies in Persons with Mild Covid-19

Among 34 volunteers who had recovered from mild Covid-19 illness, antiviral antibodies to the receptor-binding domain of the viral spike protein declined with a mean half-life of approximately 36 days after recovery. Whether these results predict the duration of viral immunity in persons recovering...

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Bibliographic Details
Published in:New England Journal of Medicine 2020-09
Main Authors: Ibarrondo, F Javier, Fulcher, Jennifer A, Goodman-Meza, David, Elliott, Julie, Hofmann, Christian, Hausner, Mary A, Ferbas, Kathie G, Tobin, Nicole H, Aldrovandi, Grace M, Yang, Otto O
Format: Article
Language:English
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Summary:Among 34 volunteers who had recovered from mild Covid-19 illness, antiviral antibodies to the receptor-binding domain of the viral spike protein declined with a mean half-life of approximately 36 days after recovery. Whether these results predict the duration of viral immunity in persons recovering from more severe cases of Covid-19 or those exposed to vaccines is unknown.
DOI:10.1056/NEJMc2025179