Synthesis of Novel Functionalized Pyrano Annulated/OxazolonePendent Chromone Derivatives as Potent Anti-Diabetic Agents

A new series of chromone based annulated coumarin and pendent oxazolone derivatives have been synthesized from 7-hydroxy-8-formyl chromone via one pot Knoevenagel condensation-ring transformation cascade. All the compounds were characterized by FTIR,1H and 13C NMR, mass, and UV spectral analysis. Th...

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Bibliographic Details
Published in:Russian journal of general chemistry 2020-01, Vol.90 (6), p.1074-1082
Main Authors: Jayaprakash, Rao Y, Abhijit, K
Format: Article
Language:English
Subjects:
Chemical synthesis
Coumarin
Derivatives
Glucosidase
Molecular docking
NMR
Nuclear magnetic resonance
Spectrum analysis
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Summary:A new series of chromone based annulated coumarin and pendent oxazolone derivatives have been synthesized from 7-hydroxy-8-formyl chromone via one pot Knoevenagel condensation-ring transformation cascade. All the compounds were characterized by FTIR,1H and 13C NMR, mass, and UV spectral analysis. The compounds have been screened for their in vitro α-glucosidase inhibition, and have demonstrated activity also supported by molecular docking. All the newly synthesized compounds exhibit excellent α-glucosidase inhibition activity compared to the reference compound Acarbose. The compound 7d has been characterized by more prominent inhibition activity with IC50 value 34.36 µM which is approximately 24 times more effective in comparison with the reference compound.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363220060225