Triple collision tumor comprising Merkel cell carcinoma with an unusual immunophenotype, squamous cell carcinoma in situ, and basal cell carcinoma

Merkel cell carcinoma (MCC) is a rare, aggressive primary cutaneous neuroendocrine cancer which almost always exhibits the cytokeratin (CK)20+/thyroid transcription factor (TTF)‐1‐ immunophenotype. MCC may occur concurrently with squamous cell carcinoma, Bowen disease, and/or basal cell carcinoma (B...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2020-08, Vol.47 (8), p.764-767
Main Authors: Hobbs, Misty M., Geers, Tyler E., Brown, Timothy S., Malone, Janine C.
Format: Article
Language:English
Subjects:
Basal cell carcinoma
CK20
collision
combined
Cytokeratin
Merkel cell
Neuroendocrine tumors
Squamous cell carcinoma
Thyroid
TTF‐1
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Summary:Merkel cell carcinoma (MCC) is a rare, aggressive primary cutaneous neuroendocrine cancer which almost always exhibits the cytokeratin (CK)20+/thyroid transcription factor (TTF)‐1‐ immunophenotype. MCC may occur concurrently with squamous cell carcinoma, Bowen disease, and/or basal cell carcinoma (BCC), with some evidence that MCCs which occur in conjunction with other neoplasms exhibit different immunophenotypes compared to pure MCC cases. We present a case of CK20‐/TTF‐1+ MCC concurrent with Bowen disease and BCC, and discuss possible differences in the pathogenesis of pure vs combined MCC. We also review the literature for this unusual immunophenotype, noting that most cases occur in combined MCC.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.13698