The relationship between insulin resistance, obesity, and endotrophin

Background Endotrophin is the cleavage product COL6. Recent findings indicate that endotrophin is actively involved in inflammation, angiogenesis, and fibrosis. It also seems to play a critical role in obesity-induced systemic insulin resistance by increasing chronic inflammation and fibrosis in adi...

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Published in:International journal of diabetes in developing countries 2020-04, Vol.40 (2), p.191-195
Main Authors: Aydin Yoldemir, Şengül, Arman, Yücel, Akarsu, Murat, Altun, Özgür, Dikker, Okan, Toprak, Ilkim Deniz, Özcan, Mustafa, Kalyon, Semih, Kutlu, Yasin, Irmak, Sedat, Toprak, Zeki, Tükek, Tufan
Format: Article
Language:English
Subjects:
Adipose tissue
Angiogenesis
Body weight
Diabetes
Family Medicine
Fasting
Fibrosis
General Practice
Health Administration
Inflammation
Insulin
Insulin resistance
Medicine
Medicine & Public Health
Obesity
Original Article
Overweight
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Summary:Background Endotrophin is the cleavage product COL6. Recent findings indicate that endotrophin is actively involved in inflammation, angiogenesis, and fibrosis. It also seems to play a critical role in obesity-induced systemic insulin resistance by increasing chronic inflammation and fibrosis in adipose tissues. In this study, we aimed to reveal the relationship between human adipose tissue, inflammation, and insulin resistance (IR). Methods The study included 51 IR patients and 37 healthy controls. The presence of IR was based on Homeostatic model of assessment-insulin resistance (HOMA-IR) level of 2, 7, or higher. Fasting plasma samples were obtained from the patients and the control group. Results The IR patients had a higher HOMA-IR, waist circumference, fasting plasma glucose (FPG), fasting insulin (FI), and triglyceride levels than the control subjects ( p  
ISSN:0973-3930
1998-3832
DOI:10.1007/s13410-019-00780-9