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Polymorphisms in PPARG and APOE: relationships with lipid profile of adolescents with cardiovascular risk factors
Background Cardiovascular diseases constitute the main death cause worldwide resulting from a combination of genetic and lifestyle factors, and the prevalence among younger individuals has increased. It is important to early identify changes in lipid profile and the influence of genetic variations i...
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| Published in: | Nutrire : revista de Sociedade Brasileira de Alimentação e Nutrição = journal of the Brazilian Society of Food and Nutrition 2017-06, Vol.42 (1), Article 13 |
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| container_title | Nutrire : revista de Sociedade Brasileira de Alimentação e Nutrição = journal of the Brazilian Society of Food and Nutrition |
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| creator | Alves, Maira Chiquito de Morais, Carla Cristina Augusto, Elaine Moura Abdalla, Dulcineia Saes Parra Horst, Maria Aderuza Cominetti, Cristiane |
| description | Background
Cardiovascular diseases constitute the main death cause worldwide resulting from a combination of genetic and lifestyle factors, and the prevalence among younger individuals has increased. It is important to early identify changes in lipid profile and the influence of genetic variations in specific genes on the individual patterns of lipid profile. Thus, the aim of this study was to verify the relationship of polymorphisms in PPAR-gamma gene (
PPARG
− rs1801282 − Pro12Ala) and in apolipoprotein E gene (
APOE −
rs429358 + rs7412, determinants of the APOE2, APOE3, or APOE4 genotypes) with lipid profile of adolescents under cardiovascular risk factors.
Methods
This was a cross-sectional study with 115 adolescents aged 10–19 years, which presented cardiovascular risk factors. The students were evaluated regarding socioeconomic, anthropometric, biochemical, genetic, and dietetic variables. Student’s
t
test or Mann-Whitney test were applied to the analysis of the genotypes. Multiple linear regression analysis was performed to determine the variables that most influenced the lipid profile.
Results
Adolescents carrying
PPARG
Ala allele showed higher serum triglycerides (
p
= 0.0423) and very low-density lipoprotein (
p
= 0.0410) levels when compared to those carrying the wild genotype. For the
APOE
polymorphism, it was observed a trend of higher triglycerides (
p
= 0.0712) and very low-density lipoprotein (
p
= 0.0758) levels in the adolescents carrying the E4 allele when compared to those who did not carry this allele.
Conclusion
The polymorphisms
PPARG
rs1801282 and
APOE
rs429358 + rs7412 seem to be related to the development of lipid profile alterations in adolescents. |
| doi_str_mv | 10.1186/s41110-017-0037-y |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2427185603</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2427185603</sourcerecordid><originalsourceid>FETCH-LOGICAL-c204y-6a6d02b358d1a012b34eb4c64ef2a7d531905ae5dcbb473928d49d3eaa6c2c343</originalsourceid><addsrcrecordid>eNp1kE1Lw0AQhhdRsNT-AG8LnqP7lU3qrZRahUKD6HnZ7G7s1jSb7qRK_r0pLejF08zhed8ZHoRuKbmnNJcPICilJCE0SwjhWdJfoBHjVCZZnonLP_s1mgBsCSGU5TKjZIT2Raj7XYjtxsMOsG9wUcxel1g3Fs-K9eIRR1frzocGNr4F_O27Da596y1uY6h87XCosLahdmBc050Jo6P14UuDOdQ64ujhE1fadCHCDbqqdA1ucp5j9P60eJs_J6v18mU-WyWGEdEnUktLWMnT3FI9_Fty4UphpHAV05lNOZ2SVLvUmrIUGZ-y3Iqp5U5raZjhgo_R3al3-HN_cNCpbTjEZjipmGAZzVNJ-EDRE2ViAIiuUm30Ox17RYk6ylUnuWqQq45yVT9k2CkDA9t8uPjb_H_oB2EMfio</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2427185603</pqid></control><display><type>article</type><title>Polymorphisms in PPARG and APOE: relationships with lipid profile of adolescents with cardiovascular risk factors</title><source>Publicly Available Content Database</source><source>Springer Link</source><creator>Alves, Maira Chiquito ; de Morais, Carla Cristina ; Augusto, Elaine Moura ; Abdalla, Dulcineia Saes Parra ; Horst, Maria Aderuza ; Cominetti, Cristiane</creator><creatorcontrib>Alves, Maira Chiquito ; de Morais, Carla Cristina ; Augusto, Elaine Moura ; Abdalla, Dulcineia Saes Parra ; Horst, Maria Aderuza ; Cominetti, Cristiane</creatorcontrib><description>Background
Cardiovascular diseases constitute the main death cause worldwide resulting from a combination of genetic and lifestyle factors, and the prevalence among younger individuals has increased. It is important to early identify changes in lipid profile and the influence of genetic variations in specific genes on the individual patterns of lipid profile. Thus, the aim of this study was to verify the relationship of polymorphisms in PPAR-gamma gene (
PPARG
− rs1801282 − Pro12Ala) and in apolipoprotein E gene (
APOE −
rs429358 + rs7412, determinants of the APOE2, APOE3, or APOE4 genotypes) with lipid profile of adolescents under cardiovascular risk factors.
Methods
This was a cross-sectional study with 115 adolescents aged 10–19 years, which presented cardiovascular risk factors. The students were evaluated regarding socioeconomic, anthropometric, biochemical, genetic, and dietetic variables. Student’s
t
test or Mann-Whitney test were applied to the analysis of the genotypes. Multiple linear regression analysis was performed to determine the variables that most influenced the lipid profile.
Results
Adolescents carrying
PPARG
Ala allele showed higher serum triglycerides (
p
= 0.0423) and very low-density lipoprotein (
p
= 0.0410) levels when compared to those carrying the wild genotype. For the
APOE
polymorphism, it was observed a trend of higher triglycerides (
p
= 0.0712) and very low-density lipoprotein (
p
= 0.0758) levels in the adolescents carrying the E4 allele when compared to those who did not carry this allele.
Conclusion
The polymorphisms
PPARG
rs1801282 and
APOE
rs429358 + rs7412 seem to be related to the development of lipid profile alterations in adolescents.</description><identifier>ISSN: 2316-7874</identifier><identifier>ISSN: 1519-8928</identifier><identifier>EISSN: 2316-7874</identifier><identifier>DOI: 10.1186/s41110-017-0037-y</identifier><language>eng</language><publisher>London: BioMed Central</publisher><subject>Clinical Nutrition ; Food Science ; Health risk assessment ; Lipids ; Medicine ; Medicine & Public Health ; Metabolic disorders ; Nutrition ; Overweight ; Risk factors ; Teenagers ; Triglycerides</subject><ispartof>Nutrire : revista de Sociedade Brasileira de Alimentação e Nutrição = journal of the Brazilian Society of Food and Nutrition, 2017-06, Vol.42 (1), Article 13</ispartof><rights>The Author(s) 2017</rights><rights>The Author(s) 2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c204y-6a6d02b358d1a012b34eb4c64ef2a7d531905ae5dcbb473928d49d3eaa6c2c343</citedby><cites>FETCH-LOGICAL-c204y-6a6d02b358d1a012b34eb4c64ef2a7d531905ae5dcbb473928d49d3eaa6c2c343</cites><orcidid>0000-0001-9972-4743</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2427185603?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,44590</link.rule.ids></links><search><creatorcontrib>Alves, Maira Chiquito</creatorcontrib><creatorcontrib>de Morais, Carla Cristina</creatorcontrib><creatorcontrib>Augusto, Elaine Moura</creatorcontrib><creatorcontrib>Abdalla, Dulcineia Saes Parra</creatorcontrib><creatorcontrib>Horst, Maria Aderuza</creatorcontrib><creatorcontrib>Cominetti, Cristiane</creatorcontrib><title>Polymorphisms in PPARG and APOE: relationships with lipid profile of adolescents with cardiovascular risk factors</title><title>Nutrire : revista de Sociedade Brasileira de Alimentação e Nutrição = journal of the Brazilian Society of Food and Nutrition</title><addtitle>Nutrire</addtitle><description>Background
Cardiovascular diseases constitute the main death cause worldwide resulting from a combination of genetic and lifestyle factors, and the prevalence among younger individuals has increased. It is important to early identify changes in lipid profile and the influence of genetic variations in specific genes on the individual patterns of lipid profile. Thus, the aim of this study was to verify the relationship of polymorphisms in PPAR-gamma gene (
PPARG
− rs1801282 − Pro12Ala) and in apolipoprotein E gene (
APOE −
rs429358 + rs7412, determinants of the APOE2, APOE3, or APOE4 genotypes) with lipid profile of adolescents under cardiovascular risk factors.
Methods
This was a cross-sectional study with 115 adolescents aged 10–19 years, which presented cardiovascular risk factors. The students were evaluated regarding socioeconomic, anthropometric, biochemical, genetic, and dietetic variables. Student’s
t
test or Mann-Whitney test were applied to the analysis of the genotypes. Multiple linear regression analysis was performed to determine the variables that most influenced the lipid profile.
Results
Adolescents carrying
PPARG
Ala allele showed higher serum triglycerides (
p
= 0.0423) and very low-density lipoprotein (
p
= 0.0410) levels when compared to those carrying the wild genotype. For the
APOE
polymorphism, it was observed a trend of higher triglycerides (
p
= 0.0712) and very low-density lipoprotein (
p
= 0.0758) levels in the adolescents carrying the E4 allele when compared to those who did not carry this allele.
Conclusion
The polymorphisms
PPARG
rs1801282 and
APOE
rs429358 + rs7412 seem to be related to the development of lipid profile alterations in adolescents.</description><subject>Clinical Nutrition</subject><subject>Food Science</subject><subject>Health risk assessment</subject><subject>Lipids</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic disorders</subject><subject>Nutrition</subject><subject>Overweight</subject><subject>Risk factors</subject><subject>Teenagers</subject><subject>Triglycerides</subject><issn>2316-7874</issn><issn>1519-8928</issn><issn>2316-7874</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp1kE1Lw0AQhhdRsNT-AG8LnqP7lU3qrZRahUKD6HnZ7G7s1jSb7qRK_r0pLejF08zhed8ZHoRuKbmnNJcPICilJCE0SwjhWdJfoBHjVCZZnonLP_s1mgBsCSGU5TKjZIT2Raj7XYjtxsMOsG9wUcxel1g3Fs-K9eIRR1frzocGNr4F_O27Da596y1uY6h87XCosLahdmBc050Jo6P14UuDOdQ64ujhE1fadCHCDbqqdA1ucp5j9P60eJs_J6v18mU-WyWGEdEnUktLWMnT3FI9_Fty4UphpHAV05lNOZ2SVLvUmrIUGZ-y3Iqp5U5raZjhgo_R3al3-HN_cNCpbTjEZjipmGAZzVNJ-EDRE2ViAIiuUm30Ox17RYk6ylUnuWqQq45yVT9k2CkDA9t8uPjb_H_oB2EMfio</recordid><startdate>20170627</startdate><enddate>20170627</enddate><creator>Alves, Maira Chiquito</creator><creator>de Morais, Carla Cristina</creator><creator>Augusto, Elaine Moura</creator><creator>Abdalla, Dulcineia Saes Parra</creator><creator>Horst, Maria Aderuza</creator><creator>Cominetti, Cristiane</creator><general>BioMed Central</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7XB</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>KB0</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0001-9972-4743</orcidid></search><sort><creationdate>20170627</creationdate><title>Polymorphisms in PPARG and APOE: relationships with lipid profile of adolescents with cardiovascular risk factors</title><author>Alves, Maira Chiquito ; de Morais, Carla Cristina ; Augusto, Elaine Moura ; Abdalla, Dulcineia Saes Parra ; Horst, Maria Aderuza ; Cominetti, Cristiane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c204y-6a6d02b358d1a012b34eb4c64ef2a7d531905ae5dcbb473928d49d3eaa6c2c343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Clinical Nutrition</topic><topic>Food Science</topic><topic>Health risk assessment</topic><topic>Lipids</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic disorders</topic><topic>Nutrition</topic><topic>Overweight</topic><topic>Risk factors</topic><topic>Teenagers</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alves, Maira Chiquito</creatorcontrib><creatorcontrib>de Morais, Carla Cristina</creatorcontrib><creatorcontrib>Augusto, Elaine Moura</creatorcontrib><creatorcontrib>Abdalla, Dulcineia Saes Parra</creatorcontrib><creatorcontrib>Horst, Maria Aderuza</creatorcontrib><creatorcontrib>Cominetti, Cristiane</creatorcontrib><collection>Springer Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Nutrire : revista de Sociedade Brasileira de Alimentação e Nutrição = journal of the Brazilian Society of Food and Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alves, Maira Chiquito</au><au>de Morais, Carla Cristina</au><au>Augusto, Elaine Moura</au><au>Abdalla, Dulcineia Saes Parra</au><au>Horst, Maria Aderuza</au><au>Cominetti, Cristiane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms in PPARG and APOE: relationships with lipid profile of adolescents with cardiovascular risk factors</atitle><jtitle>Nutrire : revista de Sociedade Brasileira de Alimentação e Nutrição = journal of the Brazilian Society of Food and Nutrition</jtitle><stitle>Nutrire</stitle><date>2017-06-27</date><risdate>2017</risdate><volume>42</volume><issue>1</issue><artnum>13</artnum><issn>2316-7874</issn><issn>1519-8928</issn><eissn>2316-7874</eissn><abstract>Background
Cardiovascular diseases constitute the main death cause worldwide resulting from a combination of genetic and lifestyle factors, and the prevalence among younger individuals has increased. It is important to early identify changes in lipid profile and the influence of genetic variations in specific genes on the individual patterns of lipid profile. Thus, the aim of this study was to verify the relationship of polymorphisms in PPAR-gamma gene (
PPARG
− rs1801282 − Pro12Ala) and in apolipoprotein E gene (
APOE −
rs429358 + rs7412, determinants of the APOE2, APOE3, or APOE4 genotypes) with lipid profile of adolescents under cardiovascular risk factors.
Methods
This was a cross-sectional study with 115 adolescents aged 10–19 years, which presented cardiovascular risk factors. The students were evaluated regarding socioeconomic, anthropometric, biochemical, genetic, and dietetic variables. Student’s
t
test or Mann-Whitney test were applied to the analysis of the genotypes. Multiple linear regression analysis was performed to determine the variables that most influenced the lipid profile.
Results
Adolescents carrying
PPARG
Ala allele showed higher serum triglycerides (
p
= 0.0423) and very low-density lipoprotein (
p
= 0.0410) levels when compared to those carrying the wild genotype. For the
APOE
polymorphism, it was observed a trend of higher triglycerides (
p
= 0.0712) and very low-density lipoprotein (
p
= 0.0758) levels in the adolescents carrying the E4 allele when compared to those who did not carry this allele.
Conclusion
The polymorphisms
PPARG
rs1801282 and
APOE
rs429358 + rs7412 seem to be related to the development of lipid profile alterations in adolescents.</abstract><cop>London</cop><pub>BioMed Central</pub><doi>10.1186/s41110-017-0037-y</doi><orcidid>https://orcid.org/0000-0001-9972-4743</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2316-7874 |
| ispartof | Nutrire : revista de Sociedade Brasileira de Alimentação e Nutrição = journal of the Brazilian Society of Food and Nutrition, 2017-06, Vol.42 (1), Article 13 |
| issn | 2316-7874 1519-8928 2316-7874 |
| language | eng |
| recordid | cdi_proquest_journals_2427185603 |
| source | Publicly Available Content Database; Springer Link |
| subjects | Clinical Nutrition Food Science Health risk assessment Lipids Medicine Medicine & Public Health Metabolic disorders Nutrition Overweight Risk factors Teenagers Triglycerides |
| title | Polymorphisms in PPARG and APOE: relationships with lipid profile of adolescents with cardiovascular risk factors |
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