Cu(I)/KOH‐Promoted Condensation between o‐Arylenediamines and Nitroarenes to Access 2‐Aryl‐2H‐Benzotriazoles

Reported is the condensation between o‐arylenediamines and nitroarenes enabled by a cooperative action of acid and base, providing a direct entry to 2‐aryl‐2H‐benzotriazoles. The potential practicability of this methodology was demonstrated by 100 mmol‐scale reactions and the synthesis of serotonin/...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2020-07, Vol.362 (14), p.2847-2851
Main Authors: Li, Hong‐Chen, Gao, Wen‐Xia, Huang, Xiao‐Bo, Zhou, Yun‐Bing, Liu, Miao‐Chang, Wu, Hua‐Yue
Format: Article
Language:English
Subjects:
Aromatic compounds
Benzotriazoles
Chemical synthesis
Condensation
Cyclization
Dopamine
Growth hormones
Nitroarenes
O-Arylenediamines
Serotonin
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Summary:Reported is the condensation between o‐arylenediamines and nitroarenes enabled by a cooperative action of acid and base, providing a direct entry to 2‐aryl‐2H‐benzotriazoles. The potential practicability of this methodology was demonstrated by 100 mmol‐scale reactions and the synthesis of serotonin/dopamine receptor ligand and human growth hormone.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202000397