A new method to amplify colorimetric signals of paper-based nanobiosensors for simple and sensitive pancreatic cancer biomarker detection

A low-cost, sensitive, and disposable paper-based immunosensor for instrument-free colorimetric detection of pancreatic cancer biomarker PEAK1 was reported for the first time by capitalizing the catalytic properties of gold nanoparticles in colour dye degradation. This simple signal amplification me...

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Bibliographic Details
Published in:Analyst (London) 2020-08, Vol.145 (15), p.5113-5117
Main Authors: Prasad, K. Sudhakara, Abugalyon, Yousef, Li, Chunqiang, Xu, Feng, Li, XiuJun
Format: Article
Language:English
Subjects:
Amplification
Biomarkers
Biomarkers, Tumor
Biosensing Techniques
Cancer
Colorimetry
Gold
Humans
Immunoassay
Immunosensors
Metal Nanoparticles
Nanoparticles
Pancreatic cancer
Pancreatic Neoplasms - diagnosis
Protein-Tyrosine Kinases
Sensitivity enhancement
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Summary:A low-cost, sensitive, and disposable paper-based immunosensor for instrument-free colorimetric detection of pancreatic cancer biomarker PEAK1 was reported for the first time by capitalizing the catalytic properties of gold nanoparticles in colour dye degradation. This simple signal amplification method enhances the detection sensitivity by about 10 fold. Catalytic properties of gold nanoparticles in colour dye degradation are utilized to amplify colorimetric detection signals of a low-cost paper-based immunosensor for instrument-free detection of pancreatic cancer biomarker PEAK1.
ISSN:0003-2654
1364-5528
DOI:10.1039/d0an00704h