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Antimicrobial susceptibility of Trueperella pyogenes isolated from food-producing ruminants

•T. pyogenes is an opportunistic pathogen causing a variety of diseases in ruminants.•Penicillin and amoxicillin are recommended for the first line of empiric treatment.•High nonsusceptible isolates to sulfamethoxazole/trimethoprim were detected.•MIC distribution yields useful information on stablis...

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Published in:Veterinary microbiology 2020-03, Vol.242, p.108593, Article 108593
Main Authors: Galán-Relaño, Ángela, Gómez-Gascón, Lidia, Barrero-Domínguez, Belén, Luque, Inmaculada, Jurado-Martos, Francisco, Vela, Ana I., Sanz-Tejero, Celia, Tarradas, Carmen
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Language:English
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Summary:•T. pyogenes is an opportunistic pathogen causing a variety of diseases in ruminants.•Penicillin and amoxicillin are recommended for the first line of empiric treatment.•High nonsusceptible isolates to sulfamethoxazole/trimethoprim were detected.•MIC distribution yields useful information on stablishing specific breakpoints. A total of 96 Trueperella pyogenes isolates, an opportunistic pathogen of food-producing ruminants, obtained from cattle (n = 34), sheep (n = 35) and goats (n = 27), and identified by Real Time PCR (qPCR), were analysed to determine the susceptibility to 12 antimicrobials commonly used in livestock, using a broth microdilution. The Minimal Inhibitory Concentration (MIC) distribution was unimodal for half of the antimicrobials tested with the exception of apramycin, gentamicin, streptomycin, oxytetracycline, tylosin, and erythromycin all of which showed bimodal MIC distributions. Low MIC90 values for penicillin, amoxicillin, ceftiofur, enrofloxacin, and gentamicin (
ISSN:0378-1135
1873-2542
DOI:10.1016/j.vetmic.2020.108593