Age-related blunting of the phagocyte arsenal and its art of killing

Phagocytosis is one of the integral parts of the host defense mechanism employed against invading pathogens. Cells which can sense and identify a pathogenic signal and can clear it by virtue of phagocytosis-dependent cell killing are known as phagocytes. Another important function of phagocytes is t...

Full description

Saved in:
Bibliographic Details
Published in:Current molecular biology reports 2020, Vol.6 (3), p.126-138
Main Authors: Das, Anindhya Sundar, Mishra, Roshnara, Bhattacharya, Sourav
Format: Article
Language:English
Subjects:
Age
Apoptosis
Biomedical and Life Sciences
Biomedicine
Homeostasis
Human Genetics
Molecular Biology of Cell Death and Aging (N Razdan and N Muhammad
Molecular Medicine
Phagocytes
Phagocytosis
Section Editors
Topical Collection on Molecular Biology of Cell Death and Aging
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Phagocytosis is one of the integral parts of the host defense mechanism employed against invading pathogens. Cells which can sense and identify a pathogenic signal and can clear it by virtue of phagocytosis-dependent cell killing are known as phagocytes. Another important function of phagocytes is the removal of apoptotic cells, crucial for maintaining tissue homeostasis. However, these essential functions of phagocytes declined with age, leading toward age-dependent immune dysfunction. In this article, we have reviewed a detailed mechanistic approach of the phagocytosis process, in the context of the age-dependent alterations of this phenomenon.
ISSN:2198-6428
2198-6428
DOI:10.1007/s40610-020-00135-y