Electrochemical Synthesis of 5‐Selenouracil Derivatives by Selenylation of Uracils

A simple and efficient electrochemical selenylation of uracils in the presence of NH4I for the synthesis of 5‐selenouracils has been developed. This transformation was performed in the transition metal‐free, oxidant‐free, and aerobic conditions, providing a rapid and practical protocol to 5‐selenour...

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Bibliographic Details
Published in:European journal of organic chemistry 2020-08, Vol.2020 (28), p.4384-4388
Main Authors: Wang, Qian, Ma, Xian‐Li, Chen, Yan‐Yan, Jiang, Cai‐Na, Xu, Yan‐Li
Format: Article
Language:English
Subjects:
Chemical synthesis
Derivatives
Electrochemistry
Nucleobases
Oxidizing agents
Selenium
Synthetic methods
Transition metals
Uracil
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Summary:A simple and efficient electrochemical selenylation of uracils in the presence of NH4I for the synthesis of 5‐selenouracils has been developed. This transformation was performed in the transition metal‐free, oxidant‐free, and aerobic conditions, providing a rapid and practical protocol to 5‐selenouracil derivatives. A simple and efficient electrochemical selenylation of uracils in the presence of NH4I for the synthesis of 5‐selenouracils has been developed. This transformation was performed in the transition metal‐free, oxidant‐free, and air conditions, providing a rapid and practical protocol to 5‐selenouracil derivatives.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202000637