Does Older Age have an Impact on Rituximab Efficacy and Safety? Results from the NOR-DMARD Register

Objective The objective of this study was to compare the efficacy and safety of rituximab in older vs younger patients with rheumatoid arthritis. Methods Data on 367 patients with rheumatoid arthritis treated with rituximab in the Norwegian Disease-Modifying Antirheumatic Drug (NOR-DMARD) register w...

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Bibliographic Details
Published in:Drugs & aging 2020-08, Vol.37 (8), p.617-626
Main Authors: Mielnik, Pawel, Sexton, Joseph, Lie, Elisabeth, Bakland, Gunnstein, Loli, Liz P., Kristianslund, Eirik K., Rødevand, Erik, Lexberg, Åse S., Kvien, Tore K.
Format: Article
Language:English
Subjects:
Adult
Age
Age Factors
Aged
Antirheumatic Agents - administration & dosage
Antirheumatic Agents - adverse effects
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - immunology
Biological products
Drug-Related Side Effects and Adverse Reactions - epidemiology
Drug-Related Side Effects and Adverse Reactions - etiology
Female
Geriatrics/Gerontology
Humans
Immunosenescence - drug effects
Immunotherapy
Infections
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Monoclonal antibodies
NCT
NCT01581294
Norway
Original Research Article
Patients
Pharmacology/Toxicology
Pharmacotherapy
Pneumonia
Registration
Registries
Rheumatoid arthritis
Rituximab - administration & dosage
Rituximab - adverse effects
Rituximab - therapeutic use
Severity of Illness Index
Treatment Outcome
Tumor necrosis factor-TNF
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Summary:Objective The objective of this study was to compare the efficacy and safety of rituximab in older vs younger patients with rheumatoid arthritis. Methods Data on 367 patients with rheumatoid arthritis treated with rituximab in the Norwegian Disease-Modifying Antirheumatic Drug (NOR-DMARD) register were analysed, comparing patients aged ≥ 65 years ( n  = 91) with patients aged 
ISSN:1170-229X
1179-1969
DOI:10.1007/s40266-020-00782-x