Association Between PSD95 Gene 3′UTR Single Nucleotide Polymorphism and Risk of Acute Ischemic Stroke in Chinese Han Population

To study the association between the 3′UTR single nucleotide polymorphism of PSD95 gene and the risk of acute ischemic stroke (AIS) in Chinese Han population. PSD95 gene 3′UTR rs191350575, rs314254, rs58197058, rs314253, rs314252, rs188777, rs11652753, rs79715480, and rs13331 genotypes of a total of...

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Bibliographic Details
Published in:Journal of molecular neuroscience 2020-09, Vol.70 (9), p.1389-1402
Main Authors: Lin, Ying-Ying, Yu, Tong-ya, Quan, Hui, Chen, Yu-Juan, Liu, Xue-Yuan, Huang, Dong-Ya
Format: Article
Language:English
Subjects:
3' Untranslated regions
Alleles
Biomedical and Life Sciences
Biomedicine
Cell Biology
Gene polymorphism
Genotypes
Health risks
High density lipoprotein
Hypertension
Interaction models
Ischemia
Loci
Low density lipoprotein
Neurochemistry
Neurology
Neurosciences
Nucleotides
Polymorphism
Population studies
Postsynaptic density proteins
Prognosis
Proteomics
Risk analysis
Risk factors
Single-nucleotide polymorphism
Stroke
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Summary:To study the association between the 3′UTR single nucleotide polymorphism of PSD95 gene and the risk of acute ischemic stroke (AIS) in Chinese Han population. PSD95 gene 3′UTR rs191350575, rs314254, rs58197058, rs314253, rs314252, rs188777, rs11652753, rs79715480, and rs13331 genotypes of a total of 280 AIS patients and 280 healthy controls were analyzed. The prognosis outcomes of all AIS patients were analyzed after 3 years of follow-up. The risk of AIS in the rs58197058 locus A allele was 1.76 times higher than the G allele (95%CI 1.53–1.92, p  
ISSN:0895-8696
1559-1166
DOI:10.1007/s12031-020-01559-y