A Mild Procedure for Enone Preparation Catalysed by Bovine Serum Albumin in a Green and Easily Available Medium

A simple and mild procedure to obtain α,β-unsaturated ketones from acetone and a set of benzaldehydes is described. The approach applies bovine serum albumin (BSA) catalysis and water or ethanol, this mild reaction medium contrasting with the strong reaction conditions of the classic aldol condensat...

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Bibliographic Details
Published in:Catalysis letters 2018-06, Vol.148 (6), p.1750-1757
Main Authors: Ardanaz, Sebastián M., Velez Rueda, Ana J., Parisi, Gustavo, Iribarren, Adolfo M., Iglesias, Luis E.
Format: Article
Language:English
Subjects:
Acetone
Albumin
Aldehydes
Analysis
Catalysis
Chemistry
Chemistry and Materials Science
Ethanol
Industrial Chemistry/Chemical Engineering
Ketones
Molecular docking
Organometallic Chemistry
Physical Chemistry
Serum albumin
Structural analysis
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Summary:A simple and mild procedure to obtain α,β-unsaturated ketones from acetone and a set of benzaldehydes is described. The approach applies bovine serum albumin (BSA) catalysis and water or ethanol, this mild reaction medium contrasting with the strong reaction conditions of the classic aldol condensation. Except for the assayed nitrobenzaldehydes, high enone yields (88–97%) were attained. In addition to its mildness, further advantages of this procedure are the use of a green catalyst exhibiting an efficient reuse and the use of eco-friendly and cheap solvents. In order to gain a deeper understanding of the involved catalytic mechanism, computational experiments on BSA structural analysis and molecular docking were carried out. Graphical Abstract
ISSN:1011-372X
1572-879X
DOI:10.1007/s10562-018-2386-4