The metabolism rationale for applying of succinate-based compositions to maintain high performance in a human organism

Design of an effective succinate-based agent for the use in sports has required a profound analysis of the main action mechanisms of the agent in question. Our paper reflects basic principles, which are decisive for the design of the offered succinate-based agent to increase the organism performance...

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Bibliographic Details
Published in:Cardiometry 2020-05 (16), p.15-25
Main Authors: Maevsky, Eugene I, Vasilieva, Anna A, Grishina, Elena V, Uchitel, Mikhail L, Bogdanova, Lyudmila A, VKozhurin, Mikhail
Format: Article
Language:English
Subjects:
Acids
Energy
Human performance
Hypoxia
Metabolism
Pharmaceuticals
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Summary:Design of an effective succinate-based agent for the use in sports has required a profound analysis of the main action mechanisms of the agent in question. Our paper reflects basic principles, which are decisive for the design of the offered succinate-based agent to increase the organism performance and the rate of recovery after intensive physical loading. We have treated a special role of the metabolic conversions of succinate in energy exchange of mithochondria: high energy efficiency, possibility of beneficial oxidation under oxygen deprivation, anaerobic formation and possible consequences of the above phenomenon. The listed key factors have determined the applications of succinate in practice in order to maintain the energy exchange as well as design a number of anti-hypoxia means. It is assumed that the treated peculiarities of the succinate metabolism can provide the basis for formation of a signal, regulatory role of this molecule in the organism environment.
ISSN:2304-7232
DOI:10.12710/cardiometry.2020.16.1525