Novel Agents in Neuropathic Pain, the Role of Capsaicin: Pharmacology, Efficacy, Side Effects, Different Preparations

Purpose of Review Capsaicin is a natural substance used to treat neuropathic pain because of its ability to be used in a more direct form on patients and efficiently treat their pain without the amount of side effects seen in the use of oral medications. Recent Findings Currently, the treatments for...

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Bibliographic Details
Published in:Current pain and headache reports 2020-09, Vol.24 (9), Article 53
Main Authors: Hall, O. Morgan, Broussard, Alaina, Range, Tierra, Carroll Turpin, Michelle A., Ellis, Savannah, Lim, Victoria M., Cornett, Elyse M., Kaye, Alan David
Format: Article
Language:English
Subjects:
Analgesics
Anesthesiology
Diabetic neuropathy
Drug dosages
Drug therapy
Internal Medicine
Medicine
Medicine & Public Health
Neuropeptides
Other Pain (N Vadivelu and AD Kaye
Pain
Pain Medicine
Pharmacology
Quality of life
Section Editors
Spinal cord
Topical Collection on Other Pain
Toxicology
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Summary:Purpose of Review Capsaicin is a natural substance used to treat neuropathic pain because of its ability to be used in a more direct form on patients and efficiently treat their pain without the amount of side effects seen in the use of oral medications. Recent Findings Currently, the treatments for neuropathic pain are, control of the underlying disease process, then focused on symptomatic relief with pharmacotherapy, topical analgesics, or other interventions. When all pharmacological agents fail to relieve the pain, interventional strategies can be considered, such as neural blocks, spinal cord stimulation, and intrathecal administered medications. The response to current treatment of neuropathic pain is only modest relief of symptoms. Multiple treatment options may be attempted, while ultimately leaving patients with refractory neuropathic pain. For these reasons, a better treatment approach to neuropathic pain is greatly needed. Summary Overall, capsaicin has great potential for becoming a first- or second-line treatment for neuropathic pain, and for becoming a therapeutic option for many other neuropathic pain-related disease states.
ISSN:1531-3433
1534-3081
DOI:10.1007/s11916-020-00886-4