Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy

Background: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems. Objective: To study the prevalence, characteristics, risk factors and outcome of AK...

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Published in:Blood Purification 2021-01, Vol.50 (1), p.102-109
Main Authors: Fominskiy, Evgeny V., Scandroglio, Anna Mara, Monti, Giacomo, Calabrò, Maria Grazia, Landoni, Giovanni, Dell’Acqua, Antonio, Beretta, Luigi, Moizo, Elena, Ravizza, Alfredo, Monaco, Fabrizio, Campochiaro, Corrado, Pieri, Marina, Azzolini, Maria Luisa, Borghi, Giovanni, Crivellari, Martina, Conte, Caterina, Mattioli, Cristina, Silvani, Paolo, Mucci, Milena, Turi, Stefano, Tentori, Stefano, Baiardo Redaelli, Martina, Sartorelli, Marianna, Angelillo, Piera, Belletti, Alessandro, Nardelli, Pasquale, Nisi, Francesco Giuseppe, Valsecchi, Gabriele, Barberio, Cristina, Ciceri, Fabio, Serpa Neto, Ary, Dagna, Lorenzo, Bellomo, Rinaldo, Zangrillo, Alberto
Format: Article
Language:English
Subjects:
Acute Kidney Injury - etiology
Acute Kidney Injury - mortality
Acute Kidney Injury - therapy
Aged
Cohort Studies
Continuous Renal Replacement Therapy
COVID-19 - complications
COVID-19 - mortality
COVID-19 - therapy
Female
Hospital Mortality
Humans
Male
Middle Aged
Prevalence
Research Article
Respiration, Artificial
Risk Factors
SARS-CoV-2 - isolation & purification
Treatment Outcome
Ventilators, Mechanical
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cited_by cdi_FETCH-LOGICAL-c452t-52a9493b2d62ab2e7e8936ae8f3a0631574a52784b7c551f44f1ff3f368264383
cites cdi_FETCH-LOGICAL-c452t-52a9493b2d62ab2e7e8936ae8f3a0631574a52784b7c551f44f1ff3f368264383
container_end_page 109
container_issue 1
container_start_page 102
container_title Blood Purification
container_volume 50
creator Fominskiy, Evgeny V.
Scandroglio, Anna Mara
Monti, Giacomo
Calabrò, Maria Grazia
Landoni, Giovanni
Dell’Acqua, Antonio
Beretta, Luigi
Moizo, Elena
Ravizza, Alfredo
Monaco, Fabrizio
Campochiaro, Corrado
Pieri, Marina
Azzolini, Maria Luisa
Borghi, Giovanni
Crivellari, Martina
Conte, Caterina
Mattioli, Cristina
Silvani, Paolo
Mucci, Milena
Turi, Stefano
Tentori, Stefano
Baiardo Redaelli, Martina
Sartorelli, Marianna
Angelillo, Piera
Belletti, Alessandro
Nardelli, Pasquale
Nisi, Francesco Giuseppe
Valsecchi, Gabriele
Barberio, Cristina
Ciceri, Fabio
Serpa Neto, Ary
Dagna, Lorenzo
Bellomo, Rinaldo
Zangrillo, Alberto
description Background: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems. Objective: To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients. Methods: Observational study in a tertiary care hospital in Milan, Italy. Results: Among 99 patients, 72 (75.0%) developed AKI and 17 (17.7%) received CRRT. Most of the patients developed stage 1 AKI (33 [45.8%]), while 15 (20.8%) developed stage 2 AKI and 24 (33.4%) a stage 3 AKI. Patients who developed AKI or needed CRRT at latest follow-up were older, and among CRRT treated patients a greater proportion had preexisting CKD. Hospital mortality was 38.9% for AKI and 52.9% for CRRT patients. Conclusions: Among invasively ventilated COVID-19 patients, AKI is very common and CRRT use is common. Both carry a high risk of in-hospital mortality.
doi_str_mv 10.1159/000508657
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Objective: To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients. Methods: Observational study in a tertiary care hospital in Milan, Italy. Results: Among 99 patients, 72 (75.0%) developed AKI and 17 (17.7%) received CRRT. Most of the patients developed stage 1 AKI (33 [45.8%]), while 15 (20.8%) developed stage 2 AKI and 24 (33.4%) a stage 3 AKI. Patients who developed AKI or needed CRRT at latest follow-up were older, and among CRRT treated patients a greater proportion had preexisting CKD. Hospital mortality was 38.9% for AKI and 52.9% for CRRT patients. Conclusions: Among invasively ventilated COVID-19 patients, AKI is very common and CRRT use is common. Both carry a high risk of in-hospital mortality.</description><identifier>ISSN: 0253-5068</identifier><identifier>EISSN: 1421-9735</identifier><identifier>DOI: 10.1159/000508657</identifier><identifier>PMID: 32659757</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Acute Kidney Injury - etiology ; Acute Kidney Injury - mortality ; Acute Kidney Injury - therapy ; Aged ; Cohort Studies ; Continuous Renal Replacement Therapy ; COVID-19 - complications ; COVID-19 - mortality ; COVID-19 - therapy ; Female ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Prevalence ; Research Article ; Respiration, Artificial ; Risk Factors ; SARS-CoV-2 - isolation &amp; purification ; Treatment Outcome ; Ventilators, Mechanical</subject><ispartof>Blood Purification, 2021-01, Vol.50 (1), p.102-109</ispartof><rights>2020 S. Karger AG, Basel</rights><rights>2020 S. Karger AG, Basel.</rights><rights>2020. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://www.karger.com/Tap/Home/278492 Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.</rights><rights>Copyright © 2020 by S. Karger AG, Basel 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-52a9493b2d62ab2e7e8936ae8f3a0631574a52784b7c551f44f1ff3f368264383</citedby><cites>FETCH-LOGICAL-c452t-52a9493b2d62ab2e7e8936ae8f3a0631574a52784b7c551f44f1ff3f368264383</cites><orcidid>0000-0003-3131-0565 ; 0000-0002-4101-800X ; 0000-0003-0407-9871 ; 0000-0002-3198-4458</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2430632099?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>780,784,885,27925,38516,43895</link.rule.ids><linktorsrc>$$Uhttps://www.proquest.com/docview/2430632099?pq-origsite=primo$$EView_record_in_ProQuest$$FView_record_in_$$GProQuest</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32659757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fominskiy, Evgeny V.</creatorcontrib><creatorcontrib>Scandroglio, Anna Mara</creatorcontrib><creatorcontrib>Monti, Giacomo</creatorcontrib><creatorcontrib>Calabrò, Maria Grazia</creatorcontrib><creatorcontrib>Landoni, Giovanni</creatorcontrib><creatorcontrib>Dell’Acqua, Antonio</creatorcontrib><creatorcontrib>Beretta, Luigi</creatorcontrib><creatorcontrib>Moizo, Elena</creatorcontrib><creatorcontrib>Ravizza, Alfredo</creatorcontrib><creatorcontrib>Monaco, Fabrizio</creatorcontrib><creatorcontrib>Campochiaro, Corrado</creatorcontrib><creatorcontrib>Pieri, Marina</creatorcontrib><creatorcontrib>Azzolini, Maria Luisa</creatorcontrib><creatorcontrib>Borghi, Giovanni</creatorcontrib><creatorcontrib>Crivellari, Martina</creatorcontrib><creatorcontrib>Conte, Caterina</creatorcontrib><creatorcontrib>Mattioli, Cristina</creatorcontrib><creatorcontrib>Silvani, Paolo</creatorcontrib><creatorcontrib>Mucci, Milena</creatorcontrib><creatorcontrib>Turi, Stefano</creatorcontrib><creatorcontrib>Tentori, Stefano</creatorcontrib><creatorcontrib>Baiardo Redaelli, Martina</creatorcontrib><creatorcontrib>Sartorelli, Marianna</creatorcontrib><creatorcontrib>Angelillo, Piera</creatorcontrib><creatorcontrib>Belletti, Alessandro</creatorcontrib><creatorcontrib>Nardelli, Pasquale</creatorcontrib><creatorcontrib>Nisi, Francesco Giuseppe</creatorcontrib><creatorcontrib>Valsecchi, Gabriele</creatorcontrib><creatorcontrib>Barberio, Cristina</creatorcontrib><creatorcontrib>Ciceri, Fabio</creatorcontrib><creatorcontrib>Serpa Neto, Ary</creatorcontrib><creatorcontrib>Dagna, Lorenzo</creatorcontrib><creatorcontrib>Bellomo, Rinaldo</creatorcontrib><creatorcontrib>Zangrillo, Alberto</creatorcontrib><creatorcontrib>COVID-BioB Study Group</creatorcontrib><creatorcontrib>for the COVID-BioB Study Group</creatorcontrib><title>Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy</title><title>Blood Purification</title><addtitle>Blood Purif</addtitle><description>Background: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems. Objective: To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients. Methods: Observational study in a tertiary care hospital in Milan, Italy. Results: Among 99 patients, 72 (75.0%) developed AKI and 17 (17.7%) received CRRT. Most of the patients developed stage 1 AKI (33 [45.8%]), while 15 (20.8%) developed stage 2 AKI and 24 (33.4%) a stage 3 AKI. Patients who developed AKI or needed CRRT at latest follow-up were older, and among CRRT treated patients a greater proportion had preexisting CKD. Hospital mortality was 38.9% for AKI and 52.9% for CRRT patients. Conclusions: Among invasively ventilated COVID-19 patients, AKI is very common and CRRT use is common. 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purification</topic><topic>Treatment Outcome</topic><topic>Ventilators, Mechanical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fominskiy, Evgeny V.</creatorcontrib><creatorcontrib>Scandroglio, Anna Mara</creatorcontrib><creatorcontrib>Monti, Giacomo</creatorcontrib><creatorcontrib>Calabrò, Maria Grazia</creatorcontrib><creatorcontrib>Landoni, Giovanni</creatorcontrib><creatorcontrib>Dell’Acqua, Antonio</creatorcontrib><creatorcontrib>Beretta, Luigi</creatorcontrib><creatorcontrib>Moizo, Elena</creatorcontrib><creatorcontrib>Ravizza, Alfredo</creatorcontrib><creatorcontrib>Monaco, Fabrizio</creatorcontrib><creatorcontrib>Campochiaro, Corrado</creatorcontrib><creatorcontrib>Pieri, Marina</creatorcontrib><creatorcontrib>Azzolini, Maria Luisa</creatorcontrib><creatorcontrib>Borghi, Giovanni</creatorcontrib><creatorcontrib>Crivellari, Martina</creatorcontrib><creatorcontrib>Conte, Caterina</creatorcontrib><creatorcontrib>Mattioli, Cristina</creatorcontrib><creatorcontrib>Silvani, Paolo</creatorcontrib><creatorcontrib>Mucci, Milena</creatorcontrib><creatorcontrib>Turi, Stefano</creatorcontrib><creatorcontrib>Tentori, Stefano</creatorcontrib><creatorcontrib>Baiardo Redaelli, Martina</creatorcontrib><creatorcontrib>Sartorelli, Marianna</creatorcontrib><creatorcontrib>Angelillo, Piera</creatorcontrib><creatorcontrib>Belletti, Alessandro</creatorcontrib><creatorcontrib>Nardelli, Pasquale</creatorcontrib><creatorcontrib>Nisi, Francesco Giuseppe</creatorcontrib><creatorcontrib>Valsecchi, Gabriele</creatorcontrib><creatorcontrib>Barberio, Cristina</creatorcontrib><creatorcontrib>Ciceri, Fabio</creatorcontrib><creatorcontrib>Serpa Neto, Ary</creatorcontrib><creatorcontrib>Dagna, Lorenzo</creatorcontrib><creatorcontrib>Bellomo, Rinaldo</creatorcontrib><creatorcontrib>Zangrillo, Alberto</creatorcontrib><creatorcontrib>COVID-BioB Study Group</creatorcontrib><creatorcontrib>for the COVID-BioB Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Coronavirus Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Blood Purification</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Fominskiy, Evgeny V.</au><au>Scandroglio, Anna Mara</au><au>Monti, Giacomo</au><au>Calabrò, Maria Grazia</au><au>Landoni, Giovanni</au><au>Dell’Acqua, Antonio</au><au>Beretta, Luigi</au><au>Moizo, Elena</au><au>Ravizza, Alfredo</au><au>Monaco, Fabrizio</au><au>Campochiaro, Corrado</au><au>Pieri, Marina</au><au>Azzolini, Maria Luisa</au><au>Borghi, Giovanni</au><au>Crivellari, Martina</au><au>Conte, Caterina</au><au>Mattioli, Cristina</au><au>Silvani, Paolo</au><au>Mucci, Milena</au><au>Turi, Stefano</au><au>Tentori, Stefano</au><au>Baiardo Redaelli, Martina</au><au>Sartorelli, Marianna</au><au>Angelillo, Piera</au><au>Belletti, Alessandro</au><au>Nardelli, Pasquale</au><au>Nisi, Francesco Giuseppe</au><au>Valsecchi, Gabriele</au><au>Barberio, Cristina</au><au>Ciceri, Fabio</au><au>Serpa Neto, Ary</au><au>Dagna, Lorenzo</au><au>Bellomo, Rinaldo</au><au>Zangrillo, Alberto</au><aucorp>COVID-BioB Study Group</aucorp><aucorp>for the COVID-BioB Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy</atitle><jtitle>Blood Purification</jtitle><addtitle>Blood Purif</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>50</volume><issue>1</issue><spage>102</spage><epage>109</epage><pages>102-109</pages><issn>0253-5068</issn><eissn>1421-9735</eissn><abstract>Background: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems. Objective: To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients. Methods: Observational study in a tertiary care hospital in Milan, Italy. Results: Among 99 patients, 72 (75.0%) developed AKI and 17 (17.7%) received CRRT. Most of the patients developed stage 1 AKI (33 [45.8%]), while 15 (20.8%) developed stage 2 AKI and 24 (33.4%) a stage 3 AKI. Patients who developed AKI or needed CRRT at latest follow-up were older, and among CRRT treated patients a greater proportion had preexisting CKD. Hospital mortality was 38.9% for AKI and 52.9% for CRRT patients. Conclusions: Among invasively ventilated COVID-19 patients, AKI is very common and CRRT use is common. Both carry a high risk of in-hospital mortality.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>32659757</pmid><doi>10.1159/000508657</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3131-0565</orcidid><orcidid>https://orcid.org/0000-0002-4101-800X</orcidid><orcidid>https://orcid.org/0000-0003-0407-9871</orcidid><orcidid>https://orcid.org/0000-0002-3198-4458</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier ISSN: 0253-5068
ispartof Blood Purification, 2021-01, Vol.50 (1), p.102-109
issn 0253-5068
1421-9735
language eng
recordid cdi_proquest_journals_2430632099
source Coronavirus Research Database
subjects Acute Kidney Injury - etiology
Acute Kidney Injury - mortality
Acute Kidney Injury - therapy
Aged
Cohort Studies
Continuous Renal Replacement Therapy
COVID-19 - complications
COVID-19 - mortality
COVID-19 - therapy
Female
Hospital Mortality
Humans
Male
Middle Aged
Prevalence
Research Article
Respiration, Artificial
Risk Factors
SARS-CoV-2 - isolation & purification
Treatment Outcome
Ventilators, Mechanical
title Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy
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