In situ detection of intracellular tissue transglutaminase based on aggregation-induced emission

Herein, a novel strategy for in situ imaging and real-time monitoring of intracellular tissue transglutaminase (TG2) is presented based on aggregation-induced emission (AIE). It has high sensitivity and specificity, minimal background signal and can also effectively distinguish different cell types...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-08, Vol.56 (63), p.9008-9011
Main Authors: Wu, Yafeng, Gao, Yaqiong, Su, Juan, Chen, Zixuan, Liu, Songqin
Format: Article
Language:English
Subjects:
Agglomeration
Cancer
Cell Line
Cysteamine - chemistry
Cysteamine - metabolism
Drug Resistance, Neoplasm - genetics
Emission
Fluorescent Dyes - chemistry
GTP-Binding Proteins - analysis
GTP-Binding Proteins - antagonists & inhibitors
GTP-Binding Proteins - metabolism
Humans
Microscopy, Confocal
Nanocomposites - chemistry
Peptides - chemistry
Peptides - metabolism
Protein Aggregates
Transglutaminases - analysis
Transglutaminases - antagonists & inhibitors
Transglutaminases - metabolism
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Summary:Herein, a novel strategy for in situ imaging and real-time monitoring of intracellular tissue transglutaminase (TG2) is presented based on aggregation-induced emission (AIE). It has high sensitivity and specificity, minimal background signal and can also effectively distinguish different cell types (drug-resistant cancer cells, cancer cells and normal cells).
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc03365k