Formulation and Evaluation of Zaltoprofen Immediate Release Tablets using Superdisintegrants

[...]in this investigation an attempt was made to develop oral disintegrating tablets of Zaltoprofen with super disintegrating agents like Explotab, Primojel, Solutab were used to super diintegrants, The superdisintegrants were taken in different ratios. [...]of the studies, the blend of all formula...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2020-03, Vol.13 (3), p.1152-1156
Main Authors: Reddy, Poreddy Srikanth, Alagarsamy, V., Bose, P. Subhash Chandra, Sarita, Damineni, Sruthi, Vuppula, Ravi, G.
Format: Article
Language:English
Subjects:
Drug dosages
Investigations
Nanoparticles
Nonsteroidal anti-inflammatory drugs
Spectrum analysis
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Summary:[...]in this investigation an attempt was made to develop oral disintegrating tablets of Zaltoprofen with super disintegrating agents like Explotab, Primojel, Solutab were used to super diintegrants, The superdisintegrants were taken in different ratios. [...]of the studies, the blend of all formulations showed good flow properties such as angle of repose, bulk density, tapped density, Carr's index, Hausner's ratio. For many drug substances, conventional immediate-release formulation provide clinically defective therapy while maintain the required balance of pharmacokinetic and pharmacodynamic profiles with an acceptable level of safety to the patient. Drug-Excipient Compatibility Stydy by Fourier Transform Infrared Spectroscopy (FTIR): The FT-IR spectra of pure Telmisartan and prepared optimized formulation of chitosan loaded nanoparticles were recorded using FTIR (Bruker Alpha-T ,Switzerland) to investigate any interaction between telmisartan and polymers in formulated nanoparticles.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2020.00212.7