Supercritical Antisolvent Process for Pharmaceutical Applications: A Review

The supercritical antisolvent (SAS) technique has been widely employed in the biomedical field, including drug delivery, to obtain drug particles or polymer-based systems of nanometric or micrometric size. The primary purpose of producing SAS particles is to improve the treatment of different pathol...

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Bibliographic Details
Published in:Processes 2020-08, Vol.8 (8), p.938
Main Authors: Franco, Paola, De Marco, Iolanda
Format: Article
Language:English
Subjects:
Antibiotics
Arthritis
Bioavailability
Context
Drug delivery
Drug delivery systems
Formulations
Nanoparticles
Overdose
Patients
Pharmaceuticals
Polymers
Principles
Side effects
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Summary:The supercritical antisolvent (SAS) technique has been widely employed in the biomedical field, including drug delivery, to obtain drug particles or polymer-based systems of nanometric or micrometric size. The primary purpose of producing SAS particles is to improve the treatment of different pathologies and to better the patient’s compliance. In this context, many active compounds have been micronized to enhance their dissolution rate and bioavailability. Aiming for more effective treatments with reduced side effects caused by drug overdose, the SAS polymer/active principle coprecipitation has mainly been proposed to offer an adequate drug release for specific therapy. The demand for new formulations with reduced side effects on the patient’s health is still growing; in this context, the SAS technique is a promising tool to solve existing issues in the biomedical field. This updated review on the use of the SAS process for clinical applications provides useful information about the achievements, the most effective polymeric carriers, and parameters, as well as future perspectives.
ISSN:2227-9717
2227-9717
DOI:10.3390/pr8080938