RETRACTED ARTICLE: 5-Fluorouracil Trapping in a Porous Ba(II)-organic Framework: Drug Delivery and Anti-thyroid Cancer Activity Evaluation

• Published in: Russian journal of coordination chemistry 2020, Vol.46 (8), p.584-591
• Main Authors: Zhang, Q. J., Zhao, J. K., Li, Y., Wu, X. Y., Ma, L. L., Ding, Z. M.
• Format: Article
• Language: English
• Subjects: Chemistry; Chemistry and Materials Science; Crystals; Dimethylformamide; Drug delivery systems; Inorganic Chemistry; Metal-organic frameworks; Physical Chemistry; Single crystals; Thyroid cancer; Toxicity; Trapping; X ray powder diffraction; X-ray diffraction
• ISSN: 1070-3284; 1608-3318
• DOI: 10.1134/S1070328420080072

Solvothermal treatment of Ba(NO 3 ) 2 with the rigid tricarboxylic acid linker 4,4′,4″-s-triazine-2,4,6-triyltribenzoic acid (H 3 TATB) in a mixture of H 2 O and N , N -dimethylformamide (DMF) produces a new three-dimensional porous metal-organic framework having the chemical formula of [Ba(HTATB)-(H 2 O) 2 ](DMF) 4 ( I ). The complex I has been characterized by powder X-ray diffraction, elemental analysis and single crystal X-ray diffraction (CIF file CCDC no. 1898532). In light of its large inner spaces as well as widely distributed open metal sites, the guest-free I ( Ia ) has been used as a crystalline vessel for trapping the anticancer drug 5-fluorouracil (5-FU), which has been investigated both experimentally and computationally. Furthermore, MTT assay was employed to evaluate the in vitro cytotoxicity of the carrier 5-FU loaded Ia against the human thyroid cancer cell lines.