Quantifying the effects of quadrupolar sinks via15N relaxation dynamics in metronidazoles hyperpolarized via SABRE-SHEATH (To the memory of Dr Kirill V. Kovtunov (PhD, 1983–2020), friend, colleague, and mentor.)

15N spin–lattice relaxation dynamics in metronidazole-15N3 and metronidazole-15N2 isotopologues are studied for rational design of 15N-enriched biomolecules for signal amplification by reversible exchange in microtesla fields. 15N relaxation dynamics mapping reveals the deleterious effects of intera...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-01, Vol.56 (64), p.9098-9101
Main Authors: Birchall, Jonathan R, Kabir, Mohammad S H, Salnikov, Oleg G, Chukanov, Nikita V, Svyatova, Alexandra, Kovtunov, Kirill V, Koptyug, Igor V, Gelovani, Juri G, Goodson, Boyd M, Pham, Wellington, Chekmenev, Eduard Y
Format: Article
Language:English
Subjects:
Biomolecules
Decay rate
Mapping
Polarization
Sheaths
Spin dynamics
Online Access:Get full text
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Summary:15N spin–lattice relaxation dynamics in metronidazole-15N3 and metronidazole-15N2 isotopologues are studied for rational design of 15N-enriched biomolecules for signal amplification by reversible exchange in microtesla fields. 15N relaxation dynamics mapping reveals the deleterious effects of interactions with the polarization transfer catalyst and a quadrupolar 14N nucleus within the spin-relayed 15N–15N network.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc03994b