Oral radiation‐induced sarcomas: Systematic review

Background The aim of this study was to integrate the available data published on radiation‐induced sarcoma of the oral cavity into an analysis of its clinical features, treatment modalities and prognostic factors. Methods An electronic search was undertaken in September 2019. The eligibility criter...

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Bibliographic Details
Published in:Head & neck 2020-09, Vol.42 (9), p.2660-2668
Main Authors: Souza, Lucas L., Pontes, Hélder A. R., Santos‐Silva, Alan R., Fernandes, Lais A., Batista, Luana A. L., Lopes, Márcio A., Khan, Waqas, Pontes, Flávia S. C.
Format: Article
Language:English
Subjects:
benign
Bone cancer
Head and neck
Latency
malignant
Mandible
Medical prognosis
Oral cavity
Osteosarcoma
radiotherapy
Sarcoma
Surgery
Survival
tumor
Tumors
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Summary:Background The aim of this study was to integrate the available data published on radiation‐induced sarcoma of the oral cavity into an analysis of its clinical features, treatment modalities and prognostic factors. Methods An electronic search was undertaken in September 2019. The eligibility criteria included publications that had enough clinical and histological information to confirm the diagnosis. Results Forty‐two publications with 122 radiation‐induced sarcoma of the oral cavities (RISOCs) were included. The mean latency period was 114 months and mean radiation total dose was 62.5 Gy. The tumors were more prevalent in males between 50 and 60 years old and the mandible was the most affected site. Osteosarcoma was the most prevalent histological type and patients were mostly treated with radical surgery. Conclusions RISOC showed a poor survival rate of 15.1% in 5‐year follow‐up. Gender and histological type were independently associated with survival.
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.26176