Nanodelivery of Nitazoxanide: Impact on the Metabolism of Taenia Crassiceps Cysticerci Intracranially Inoculated in Mice

Aim: To formulate nanocapsules and nanoemulsions of nitazoxanide (NTZ) and evaluate the metabolic effect on Taenia crassiceps cysticerci inoculated intracranially into mice. Materials & methods: NTZ nanosystems were formulated through solvent diffusion methodology. These nanoformulations were ad...

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Bibliographic Details
Published in:Therapeutic delivery 2020-05, Vol.11 (5), p.329-339
Main Authors: Vinaud, Marina Claire, Real, Daniel, Fraga, Carolina Miguel, Lima, Nayana F, Souza Lino Junior, Ruy De, Leonardi, Darío, J Salomon, Claudio
Format: Article
Language:English
Subjects:
Antiviral drugs
Bioavailability
Enzymes
Ethanol
Gluconeogenesis
Glycolysis
Infections
Laboratory animals
Metabolic pathways
Metabolism
Nanotechnology
Particle size
Spectrum analysis
Studies
Taenia crassiceps
Tricarboxylic acid cycle
Tropical diseases
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Summary:Aim: To formulate nanocapsules and nanoemulsions of nitazoxanide (NTZ) and evaluate the metabolic effect on Taenia crassiceps cysticerci inoculated intracranially into mice. Materials & methods: NTZ nanosystems were formulated through solvent diffusion methodology. These nanoformulations were administered perorally and their impact on glycolysis, the tricarboxylic acid cycle and fatty acid metabolism in T. crassiceps cysticerci was investigated. Results: Gluconeogenesis and protein catabolism were significantly increased by the nanoformulations when compared with the control group and the NTZ-treated group. All the other metabolic pathways were inhibited by the nanoformulation treatments. Conclusion: The remarkable metabolic modifications that occur in this in vivo model through the application of these developed nanosystems confirm their capability to deliver NTZ into targeted tissues.
ISSN:2041-5990
2041-6008
DOI:10.4155/tde-2020-0017