The synthesis of new acyclic analogs of 3-phenacyluridine and comparative evaluation of their in vivo biological activity

New structural analogs of 3-phenacyluridine were obtained as a result of N (3)-alkylation of 1-(2-acetoxyethyl)- and 1-(2-acetoxyethoxymethyl) uracil. Biological studies of the title compounds in an acute in vivo experiment did not reveal their hypnotic properties and ability to enhance the effects...

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Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2020-06, Vol.56 (6), p.769-775
Main Authors: Novakov, Ivan А., Brunilina, Leila L., Kirillov, Ivan А., Nawrozkij, Maxim B., Robinovich, Mariya D., Titova, Evgeniya S., Sheikin, Dmitry S., Ruchko, Evsey А., Pavlova, Alla V., Kotlyarova, Anastasiya А., Tolstikova, Tatyana G.
Format: Article
Language:English
Subjects:
Alkylation
Analogs
Benzodiazepines
Biological activity
Chemistry
Chemistry and Materials Science
Chloral
Comparative analysis
Diazepam
In vivo methods and tests
Organic Chemistry
Pharmacy
Technical institutes
Uracil
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Summary:New structural analogs of 3-phenacyluridine were obtained as a result of N (3)-alkylation of 1-(2-acetoxyethyl)- and 1-(2-acetoxyethoxymethyl) uracil. Biological studies of the title compounds in an acute in vivo experiment did not reveal their hypnotic properties and ability to enhance the effects of diazepam and chloral hydrate.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-020-02729-x