Protective effects of Allium sativum essential oil rich in disulfides against deltamethrin induced oxidative stress and hepatotoxicity in rats

The purpose of our study was to evaluate the antioxidant potential of Allium sativum essential oil (ASEO) and the protective effects against deltamethrin (D) induced hepatic toxic effects in Wistar rats. Twenty-four male rats were divided into four groups as follows: control, ASEO, D and ASEO + D. R...

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Published in:Journal of food measurement & characterization 2020-10, Vol.14 (5), p.2667-2675
Main Authors: Ncir, Marwa, Ben Ali, Manel, Sellami, Hanen, Allagui, Mohamed Salah, Lahyani, Amina, Makni Ayadi, Fatma, Boudawara, Tahia, Allouche, Noureddine, El Feki, Abdelfattah, Saoudi, Mongi
Format: Article
Language:English
Subjects:
Alanine
Alanine transaminase
Alkaline phosphatase
Allium sativum
Antioxidants
Aspartate aminotransferase
Biocompatibility
Bleaching
Body weight
Carbonyl compounds
Carbonyls
Carotene
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Deltamethrin
Disulfides
Engineering
Essential oils
Eugenol
Food Science
Garlic
Hepatotoxicity
In vivo methods and tests
Lipid peroxidation
Lipids
Liver
Oils & fats
Original Paper
Oxidative stress
Peroxidation
Pretreatment
Proteins
Scavenging
Toxicity
β-Carotene
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Sellami, Hanen
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Allouche, Noureddine
El Feki, Abdelfattah
Saoudi, Mongi
description The purpose of our study was to evaluate the antioxidant potential of Allium sativum essential oil (ASEO) and the protective effects against deltamethrin (D) induced hepatic toxic effects in Wistar rats. Twenty-four male rats were divided into four groups as follows: control, ASEO, D and ASEO + D. Rats were orally gavaged with ASEO (200 mg/kg body weight) and D (7.2 mg/kg body weight) for 4 weeks. The ASEO revealed radical scavenging activity (DPPH) with IC 50  = 47.66 ± 2.51 µg/mL, and the lipid peroxidation activity (the β-carotene bleaching method) with IC 50  = 0.034 ± 0.007 µg/mL. Analyzed by GC–MS, ASEO confirm that disulfides (38%) and eugenol (15%) were the main components of garlic oil. In terms of in vivo study, deltamethrin exposure induced a significant increase in the biochemical serum parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), hepatic lipid peroxidation (LPO) level, advanced oxidized protein products (AOPP), and carbonyl protein accompanied by decrease in the activities of SOD, CAT, GPX and the levels of GSH (p 
doi_str_mv 10.1007/s11694-020-00513-1
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subjects Alanine
Alanine transaminase
Alkaline phosphatase
Allium sativum
Antioxidants
Aspartate aminotransferase
Biocompatibility
Bleaching
Body weight
Carbonyl compounds
Carbonyls
Carotene
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Deltamethrin
Disulfides
Engineering
Essential oils
Eugenol
Food Science
Garlic
Hepatotoxicity
In vivo methods and tests
Lipid peroxidation
Lipids
Liver
Oils & fats
Original Paper
Oxidative stress
Peroxidation
Pretreatment
Proteins
Scavenging
Toxicity
β-Carotene
title Protective effects of Allium sativum essential oil rich in disulfides against deltamethrin induced oxidative stress and hepatotoxicity in rats
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