Indolizine synthesis via copper-catalyzed cyclization of gem-difluoroalkenes and 2-(pyridin-2-yl)acetate derivatives

A novel and versatile approach to construct substituted indolizines through copper-catalyzed coupling cyclization of 2-(pyridin-2-yl)acetate with gem-difluoroalkenes has been developed. This method takes advantage of the cleavage of C–F bonds, providing a straightforward and efficient access to a va...

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Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2020-08, Vol.7 (16), p.2313-2318
Main Authors: Chuan-Jun, Lu, Yu, Xin, Yu-Ting, Chen, Qing-Bao, Song, Wang, Hong
Format: Article
Language:English
Subjects:
Acetic acid
Chemical synthesis
Copper
Derivatives
Functional groups
NMR
Nuclear magnetic resonance
Organic chemistry
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Summary:A novel and versatile approach to construct substituted indolizines through copper-catalyzed coupling cyclization of 2-(pyridin-2-yl)acetate with gem-difluoroalkenes has been developed. This method takes advantage of the cleavage of C–F bonds, providing a straightforward and efficient access to a variety of bisubstituted indolizine derivatives in moderate to good yields with brilliant functional group compatibility.
ISSN:2052-4110
2052-4110
DOI:10.1039/d0qo00553c