Noninvasive ultrasound deep brain stimulation of nucleus accumbens induces behavioral avoidance

Ultrasound stimulation is an emerging noninvasive option in treating neuropsychiatric disorders. The present study investigates the behavioral alterations resulting from ultrasound stimulation on the nucleus accumbens (NAc) in freely moving mice. Our results show that an acute ultrasound stimulation...

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Bibliographic Details
Published in:Science China. Life sciences 2020-09, Vol.63 (9), p.1328-1336
Main Authors: Niu, Lili, Guo, Yanchen, Lin, Zhengrong, Shi, Zhe, Bian, Tianyuan, Qi, Lin, Meng, Long, Grace, Anthony A., Zheng, Hairong, Yuan, Ti-Fei
Format: Article
Language:English
Subjects:
Animals
Aversion
Avoidance behavior
Avoidance Learning - drug effects
Biomedical and Life Sciences
Conditioning, Psychological - drug effects
Cortex (auditory)
Deep Brain Stimulation
Kinetics
Life Sciences
Male
Mental disorders
Mice, Inbred C57BL
Morphine
Morphine - administration & dosage
Morphine - adverse effects
Morphine Dependence - metabolism
Nucleus accumbens
Nucleus Accumbens - drug effects
Place preference conditioning
Research Paper
Sensory integration
Ultrasonic imaging
Ultrasonic Waves - adverse effects
Ultrasound
Visual cortex
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Summary:Ultrasound stimulation is an emerging noninvasive option in treating neuropsychiatric disorders. The present study investigates the behavioral alterations resulting from ultrasound stimulation on the nucleus accumbens (NAc) in freely moving mice. Our results show that an acute ultrasound stimulation on the NAc, rather than the visual cortex or auditory cortex, led to a pronounced avoidance behavior, while repeated NAc ultrasound stimulation resulted in an obvious conditioned place aversion with changes in synaptic protein (GluA1/2 subunit) expression. Notably, NAc ultrasound stimulation suppressed the morphine-induced conditioned place preference. The results provide evidence that NAc ultrasound stimulation can be applied as a potential noninvasive therapeutic option in treating psychiatric disorders.
ISSN:1674-7305
1869-1889
DOI:10.1007/s11427-019-1616-6