In-vitro release study of Diclofenac sodium from topical gel formulations using diffusion cell

The present research study was to explore the in-vitro drug release and kinetics of different brands of diclofenac sodium gel formulations (Brand A, B, C) available in the local pharmaceutical market of Tamilnadu with a lab made reference gel by using vertical diffusion cell through synthetic membra...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2020, Vol.13 (6), p.2901-2905
Main Authors: Maanvizhi, Saba, Iyyappan, V., Bhavishi, P. G.
Format: Article
Language:English
Subjects:
Drug dosages
Kinetics
Nonsteroidal anti-inflammatory drugs
Osteoarthritis
Pharmaceuticals
Rheumatoid arthritis
Sodium
Online Access:Get full text
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Summary:The present research study was to explore the in-vitro drug release and kinetics of different brands of diclofenac sodium gel formulations (Brand A, B, C) available in the local pharmaceutical market of Tamilnadu with a lab made reference gel by using vertical diffusion cell through synthetic membrane. [...]topical gel formulations are preferred over oral administration2. [...]the therapeutic effects of the drugs gets achieved effectively whereas the systemic side effects can be avoided or minimized. [...]the oil phase was then added into aqueous gel phase under continuous stirring for 10 minutes to obtain a homogeneous dispersion of gel21.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2020.00517.X