Neuroprotective effect of Conessinin on Elevated oxidative stress induced Alzheimers'disease in rats

Aim: The present study aimed to investigate the effects of Conessine on neurobehavioral activity and superoxide dismutase (SOD), glutathione reductase (GRx) and catalase (CAT) enzymes activity, malondialdehyde (MDA) levels in hippocampal area of rats in an experimental model of AD. [...]the genetic...

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Published in:Research journal of pharmacy and technology 2020, Vol.13 (6), p.2703-2707
Main Authors: Bandaru, Nagaraju, Komavari, Chandrasekhar, Gorla, Uma Sankar, Koteswarao, GSN, Kulandaivelu, Umasankar, Ankarao, A.
Format: Article
Language:English
Subjects:
Alzheimer's disease
Antioxidants
Brain
Cognitive ability
Dementia
Enzymes
Lipid peroxidation
Lipids
Memory
Oxidative stress
Proteins
Rodents
Stainless steel
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Summary:Aim: The present study aimed to investigate the effects of Conessine on neurobehavioral activity and superoxide dismutase (SOD), glutathione reductase (GRx) and catalase (CAT) enzymes activity, malondialdehyde (MDA) levels in hippocampal area of rats in an experimental model of AD. [...]the genetic and biochemical information demonstrating that oxidative stress is increase in AD and treatment with antioxidants has been useful in animal models. All procedures in this study were in agreement with the Guide of Care and were approved by the ethics committee on animal experimentation of the Shri Vishnu College of Pharmacy. 30 male Wistar rats weighting 220 ± 20g at the time were used. The supernatant was separated and used for assays of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GRX) activities, malondialdehyde (MDA) and protein level content. 2.2.4.Determination of SOD activity:
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2020.00481.3