Spectrophotometric method for the estimation of Atorvastatin calcium in pharmaceutical preparation

Atorvastatin calcium is a member of the drug class known as statins, used for lowering blood cholesterol chemically, it is (3R, 5R)-7-(2-(4-fluropenyl) -3-phenyl-4- (phenylcarbamoy1)-5-propan- 2ylpyrrol -1-yl)-3, 5-dihydroxyheptanoicacid, it works by inhibiting 3-hydroxy 3-methyl glutaryl co-enzyme...

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Bibliographic Details
Published in:Asian Journal of Pharmaceutical Analysis 2020-06, Vol.10 (2), p.77
Main Authors: Urs, S. Subramanya Raj, Gangambika, H.M., Murthy, M. Rajashekara, Asharani, D.R.
Format: Article
Language:English
Subjects:
Accuracy
Calibration
Cardiovascular disease
Cholesterol
Drug dosages
Enzymes
Methods
Pharmaceutical industry
Pharmaceuticals
Statins
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Summary:Atorvastatin calcium is a member of the drug class known as statins, used for lowering blood cholesterol chemically, it is (3R, 5R)-7-(2-(4-fluropenyl) -3-phenyl-4- (phenylcarbamoy1)-5-propan- 2ylpyrrol -1-yl)-3, 5-dihydroxyheptanoicacid, it works by inhibiting 3-hydroxy 3-methyl glutaryl co-enzyme (HMG-CoA) reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body. Literature survey revealed that no simple UV method has been reported to the best of our knowledge. so emphasis was given to develop simple, sensitive, selective, precise and accurate UV method for determination of atorvastatin calcium, therefore in the proposed methods 2M urea and 2M thiourea solution is used as hydrotropic solubilizing agent to enhance the aqueous solubilities of atorvastatin calcium in dosage forms. The wavelength of absorption maxima were determined for drug Atorvastatin calcium showed maximum absorbance at 246nm (method 1), 240nm (method 2 and 3) Calibration Plot of Absoprtion Maxima Calibration curve: METHOD 1 Standard calibration curve for atorvastatin, covering the range 5-35 µg/ml, prepared by serial dilution with methanol for pure drug and tablet formulation were developed and validated. The results of solubility studies indicated that enhancement in aqueous solubility of atorvastatinn calcium in 2.0 M urea solution and was more than 6-7 folds as compared to their solubilities in distilled water. [...]this solution was employed to extract atorvastatin calcium from the fine powder of tablet formulation and thus analysis will become easier one.
ISSN:2231-5667
2231-5675
DOI:10.5958/2231-5675.2020.00013.7