Uptake, Accumulation, and Biomarkers of PM2.5-Associated Organophosphate Flame Retardants in C57BL/6 Mice after Chronic Exposure at Real Environmental Concentrations

Although the bioaccumulation of organophosphate flame retardants (OPFRs) in aquatic organisms has been investigated, little information is available about their bioaccumulation in mammals following chronic inhalation exposure. To address this knowledge gap, C57BL/6 mice were exposed to 7 PM2.5-assoc...

Full description

Saved in:
Bibliographic Details
Published in:Environmental science & technology 2020-08, Vol.54 (15), p.9519-9528
Main Authors: Chen, Min, Liao, Xiaoliang, Yan, Shi-chao, Gao, Yanpeng, Yang, Chun, Song, Yuanyuan, Liu, Yi, Li, Weiquan, Tsang, Suk-Ying, Chen, Zhi-Feng, Qi, Zenghua, Cai, Zongwei
Format: Article
Language:English
Subjects:
Animal tissues
Aquatic organisms
Bioaccumulation
Biomarkers
Chronic exposure
Congeners
Dosage
Ecotoxicology and Public Health
Exposure
Flame retardants
Health risks
Inhalation
Intestine
Kidneys
Mammals
Metabolites
Muscles
Octanol
Organophosphates
Particulate matter
Respiration
Retardants
Spleen
Trachea
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although the bioaccumulation of organophosphate flame retardants (OPFRs) in aquatic organisms has been investigated, little information is available about their bioaccumulation in mammals following chronic inhalation exposure. To address this knowledge gap, C57BL/6 mice were exposed to 7 PM2.5-associated OPFRs via the trachea to study their bioaccumulation, tissue distribution, and urinary metabolites. Low (corresponding to the real PM2.5 concentrations occurring during winter in Guangzhou), medium, and high dosages were examined. After 72 days’ exposure, ∑OPFR concentrations in tissues from mice in the medium dosage group decreased in the order of intestine > heart > stomach > testis > kidney > spleen > brain > liver > lung > muscle. Of the OPFRs detected in all three exposure groups, chlorinated alkyl OPFRs were most heavily accumulated in mice. We found a significant positive correlation between the bioaccumulation ratio and octanol–air partition coefficient (K OA) in mice tissues for low log K OW OPFR congeners (log K OW ≤ 4, p < 0.05). Three urinary metabolites (di-p-cresyl phosphate: DCrP, diphenyl phosphate: DPhP, dibutyl phosphate: DnBP) were detected from the high dosage group. These results provide important insights into the bioaccumulation potential of OPFRs in mammals and emphasize the health risk of chlorinated alkyl OPFRs.
ISSN:0013-936X
1520-5851
DOI:10.1021/acs.est.0c02237