A role of sea buckthorn on Alzheimer’s disease

Summary Evidence suggests that diets rich in antioxidants reduce the risk factors of Alzheimer’s disease (AD). Hippophae rhamnoides, commonly known as sea buckthorn (SB), is rich in antioxidants which could have direct effects on amyloid‐beta (Aβ) levels and consequently influence AD pathogenesis. I...

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Bibliographic Details
Published in:International journal of food science & technology 2020-09, Vol.55 (9), p.3073-3081
Main Authors: Dong, Ke, Fernando, Warnakulasuriya M. A. D. Binosha, Durham, Rosalie, Stockmann, Regine, W. Jayatunga, Dona Pamoda, Jayasena, Vijay
Format: Article
Language:English
Subjects:
AFM
Alzheimer's disease
amyloid beta
Antioxidants
Cell viability
Chemical compounds
ELISA
Neurodegenerative diseases
Pathogenesis
Pharmacology
Risk analysis
Risk factors
Sea buckthorn
Western blotting
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Summary:Summary Evidence suggests that diets rich in antioxidants reduce the risk factors of Alzheimer’s disease (AD). Hippophae rhamnoides, commonly known as sea buckthorn (SB), is rich in antioxidants which could have direct effects on amyloid‐beta (Aβ) levels and consequently influence AD pathogenesis. In this study, sea buckthorn powder (SBP) was administered at varying concentrations (0.6, 0.9, 1.2, 1.5 and 1.8 µg mL−1) to cell cultures (BE(2)‐M17) with 20 mm Aβ for 72 h. MTS test indicated that SB significantly increased cell viability in Aβ‐induced cells up to 95%. Results of Western blot showed maximum 38% inhibition of Aβ compared to the control (Aβ only). ELISA demonstrated significantly lower amyloid‐β level (6672 pg mL−1) than the control (10189 pg mL−1). Images of AFM further confirmed the presence of low quantity of amyloid beta in SBP‐treated cells. These findings suggest that SB warrants further investigation as potential therapeutic agent in the treatment of AD. This research has outlined the role of sea buckthorn on Alzheimer’s disease. Significant reduction of amyloid beta concentration was observed in MTS, BCA, Western blot, ELISA and AFM since sea buckthorn powder was treated with cells.
ISSN:0950-5423
1365-2621
DOI:10.1111/ijfs.14571