Radiochemical separation of no-carrier-added 186Re from proton irradiated tungsten target

Rhenium-186 [ t ½  = 3.7 d, 1.07 MeV β − -particles, 137 keV γ-ray] is an emerging radioisotope which holds tremendous potential in preparation of theranostic radiopharmaceuticals. This radioisotope was produced in a no-carrier-added form by irradiation of enriched 186 W target via 186 W(p, n) 186 R...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2020, Vol.325 (3), p.875-883
Main Authors: Ram, Ramu, Chakravarty, Rubel, Jadhav, Sachin, Chakraborty, Sudipta, Jagadeesan, K. C., Thakare, S. V., Dash, Ashutosh
Format: Article
Language:English
Subjects:
Aluminum oxide
Chemistry
Chemistry and Materials Science
Column chromatography
Diagnostic Radiology
Hadrons
Heavy Ions
Inorganic Chemistry
Nuclear Chemistry
Nuclear Physics
Physical Chemistry
Proton irradiation
Radiochemical separation
Radioisotopes
Rhenium
Rhenium isotopes
Solvent extraction
Sorbents
Tungsten
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Summary:Rhenium-186 [ t ½  = 3.7 d, 1.07 MeV β − -particles, 137 keV γ-ray] is an emerging radioisotope which holds tremendous potential in preparation of theranostic radiopharmaceuticals. This radioisotope was produced in a no-carrier-added form by irradiation of enriched 186 W target via 186 W(p, n) 186 Re reaction in a pelletron. A facile radiochemical separation procedure based on selective solvent extraction in methylethyl ketone medium followed by column chromatography using mesoporous alumina sorbent has been developed to obtain 186 Re in a form suitable for radiopharmaceutical preparation. This approach is expected to promote widespread utilization of this radioisotope for the benefit of cancer patients.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-020-07207-4