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Radiochemical separation of no-carrier-added 186Re from proton irradiated tungsten target
Rhenium-186 [ t ½ = 3.7 d, 1.07 MeV β − -particles, 137 keV γ-ray] is an emerging radioisotope which holds tremendous potential in preparation of theranostic radiopharmaceuticals. This radioisotope was produced in a no-carrier-added form by irradiation of enriched 186 W target via 186 W(p, n) 186 R...
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Published in: | Journal of radioanalytical and nuclear chemistry 2020, Vol.325 (3), p.875-883 |
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container_issue | 3 |
container_start_page | 875 |
container_title | Journal of radioanalytical and nuclear chemistry |
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creator | Ram, Ramu Chakravarty, Rubel Jadhav, Sachin Chakraborty, Sudipta Jagadeesan, K. C. Thakare, S. V. Dash, Ashutosh |
description | Rhenium-186 [
t
½
= 3.7 d, 1.07 MeV β
−
-particles, 137 keV γ-ray] is an emerging radioisotope which holds tremendous potential in preparation of theranostic radiopharmaceuticals. This radioisotope was produced in a no-carrier-added form by irradiation of enriched
186
W target via
186
W(p, n)
186
Re reaction in a pelletron. A facile radiochemical separation procedure based on selective solvent extraction in methylethyl ketone medium followed by column chromatography using mesoporous alumina sorbent has been developed to obtain
186
Re in a form suitable for radiopharmaceutical preparation. This approach is expected to promote widespread utilization of this radioisotope for the benefit of cancer patients. |
doi_str_mv | 10.1007/s10967-020-07207-4 |
format | article |
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t
½
= 3.7 d, 1.07 MeV β
−
-particles, 137 keV γ-ray] is an emerging radioisotope which holds tremendous potential in preparation of theranostic radiopharmaceuticals. This radioisotope was produced in a no-carrier-added form by irradiation of enriched
186
W target via
186
W(p, n)
186
Re reaction in a pelletron. A facile radiochemical separation procedure based on selective solvent extraction in methylethyl ketone medium followed by column chromatography using mesoporous alumina sorbent has been developed to obtain
186
Re in a form suitable for radiopharmaceutical preparation. This approach is expected to promote widespread utilization of this radioisotope for the benefit of cancer patients.</description><identifier>ISSN: 0236-5731</identifier><identifier>EISSN: 1588-2780</identifier><identifier>DOI: 10.1007/s10967-020-07207-4</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aluminum oxide ; Chemistry ; Chemistry and Materials Science ; Column chromatography ; Diagnostic Radiology ; Hadrons ; Heavy Ions ; Inorganic Chemistry ; Nuclear Chemistry ; Nuclear Physics ; Physical Chemistry ; Proton irradiation ; Radiochemical separation ; Radioisotopes ; Rhenium ; Rhenium isotopes ; Solvent extraction ; Sorbents ; Tungsten</subject><ispartof>Journal of radioanalytical and nuclear chemistry, 2020, Vol.325 (3), p.875-883</ispartof><rights>Akadémiai Kiadó, Budapest, Hungary 2020</rights><rights>Akadémiai Kiadó, Budapest, Hungary 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1644-66b9e95b30b7e4cac05a16baf7651287c55c8aa32b76a8c524a999d67ba27de03</citedby><cites>FETCH-LOGICAL-c1644-66b9e95b30b7e4cac05a16baf7651287c55c8aa32b76a8c524a999d67ba27de03</cites><orcidid>0000-0003-2125-8636</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids></links><search><creatorcontrib>Ram, Ramu</creatorcontrib><creatorcontrib>Chakravarty, Rubel</creatorcontrib><creatorcontrib>Jadhav, Sachin</creatorcontrib><creatorcontrib>Chakraborty, Sudipta</creatorcontrib><creatorcontrib>Jagadeesan, K. C.</creatorcontrib><creatorcontrib>Thakare, S. V.</creatorcontrib><creatorcontrib>Dash, Ashutosh</creatorcontrib><title>Radiochemical separation of no-carrier-added 186Re from proton irradiated tungsten target</title><title>Journal of radioanalytical and nuclear chemistry</title><addtitle>J Radioanal Nucl Chem</addtitle><description>Rhenium-186 [
t
½
= 3.7 d, 1.07 MeV β
−
-particles, 137 keV γ-ray] is an emerging radioisotope which holds tremendous potential in preparation of theranostic radiopharmaceuticals. This radioisotope was produced in a no-carrier-added form by irradiation of enriched
186
W target via
186
W(p, n)
186
Re reaction in a pelletron. A facile radiochemical separation procedure based on selective solvent extraction in methylethyl ketone medium followed by column chromatography using mesoporous alumina sorbent has been developed to obtain
186
Re in a form suitable for radiopharmaceutical preparation. This approach is expected to promote widespread utilization of this radioisotope for the benefit of cancer patients.</description><subject>Aluminum oxide</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Column chromatography</subject><subject>Diagnostic Radiology</subject><subject>Hadrons</subject><subject>Heavy Ions</subject><subject>Inorganic Chemistry</subject><subject>Nuclear Chemistry</subject><subject>Nuclear Physics</subject><subject>Physical Chemistry</subject><subject>Proton irradiation</subject><subject>Radiochemical separation</subject><subject>Radioisotopes</subject><subject>Rhenium</subject><subject>Rhenium isotopes</subject><subject>Solvent extraction</subject><subject>Sorbents</subject><subject>Tungsten</subject><issn>0236-5731</issn><issn>1588-2780</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMoWKt_wNOC5-gk2XwdpfgFBaHowVOYzWbrlna3JunBf290BW-e5jDP-87wEHLJ4JoB6JvEwCpNgQMFzUHT-ojMmDSGcm3gmMyAC0WlFuyUnKW0AQBrjJiRtxW2_ejfw673uK1S2GPE3I9DNXbVMFKPMfYhUmzb0FbMqFWoujjuqn0cc6H6GEsB5rLMh2GdchiqjHEd8jk56XCbwsXvnJPX-7uXxSNdPj88LW6X1DNV11SpxgYrGwGNDrVHDxKZarDTSjJutJfSG0TBG63QeMlrtNa2SjfIdRtAzMnV1Fs--jiElN1mPMShnHS8FsYayywrFJ8oH8eUYujcPvY7jJ-OgftW6CaFrih0PwpdXUJiCqUCD-sQ_6r_SX0BrmZ0Jw</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Ram, Ramu</creator><creator>Chakravarty, Rubel</creator><creator>Jadhav, Sachin</creator><creator>Chakraborty, Sudipta</creator><creator>Jagadeesan, K. C.</creator><creator>Thakare, S. V.</creator><creator>Dash, Ashutosh</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-2125-8636</orcidid></search><sort><creationdate>2020</creationdate><title>Radiochemical separation of no-carrier-added 186Re from proton irradiated tungsten target</title><author>Ram, Ramu ; Chakravarty, Rubel ; Jadhav, Sachin ; Chakraborty, Sudipta ; Jagadeesan, K. C. ; Thakare, S. V. ; Dash, Ashutosh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1644-66b9e95b30b7e4cac05a16baf7651287c55c8aa32b76a8c524a999d67ba27de03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aluminum oxide</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Column chromatography</topic><topic>Diagnostic Radiology</topic><topic>Hadrons</topic><topic>Heavy Ions</topic><topic>Inorganic Chemistry</topic><topic>Nuclear Chemistry</topic><topic>Nuclear Physics</topic><topic>Physical Chemistry</topic><topic>Proton irradiation</topic><topic>Radiochemical separation</topic><topic>Radioisotopes</topic><topic>Rhenium</topic><topic>Rhenium isotopes</topic><topic>Solvent extraction</topic><topic>Sorbents</topic><topic>Tungsten</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ram, Ramu</creatorcontrib><creatorcontrib>Chakravarty, Rubel</creatorcontrib><creatorcontrib>Jadhav, Sachin</creatorcontrib><creatorcontrib>Chakraborty, Sudipta</creatorcontrib><creatorcontrib>Jagadeesan, K. C.</creatorcontrib><creatorcontrib>Thakare, S. V.</creatorcontrib><creatorcontrib>Dash, Ashutosh</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of radioanalytical and nuclear chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ram, Ramu</au><au>Chakravarty, Rubel</au><au>Jadhav, Sachin</au><au>Chakraborty, Sudipta</au><au>Jagadeesan, K. C.</au><au>Thakare, S. V.</au><au>Dash, Ashutosh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiochemical separation of no-carrier-added 186Re from proton irradiated tungsten target</atitle><jtitle>Journal of radioanalytical and nuclear chemistry</jtitle><stitle>J Radioanal Nucl Chem</stitle><date>2020</date><risdate>2020</risdate><volume>325</volume><issue>3</issue><spage>875</spage><epage>883</epage><pages>875-883</pages><issn>0236-5731</issn><eissn>1588-2780</eissn><abstract>Rhenium-186 [
t
½
= 3.7 d, 1.07 MeV β
−
-particles, 137 keV γ-ray] is an emerging radioisotope which holds tremendous potential in preparation of theranostic radiopharmaceuticals. This radioisotope was produced in a no-carrier-added form by irradiation of enriched
186
W target via
186
W(p, n)
186
Re reaction in a pelletron. A facile radiochemical separation procedure based on selective solvent extraction in methylethyl ketone medium followed by column chromatography using mesoporous alumina sorbent has been developed to obtain
186
Re in a form suitable for radiopharmaceutical preparation. This approach is expected to promote widespread utilization of this radioisotope for the benefit of cancer patients.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s10967-020-07207-4</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2125-8636</orcidid></addata></record> |
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language | eng |
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source | Springer Nature |
subjects | Aluminum oxide Chemistry Chemistry and Materials Science Column chromatography Diagnostic Radiology Hadrons Heavy Ions Inorganic Chemistry Nuclear Chemistry Nuclear Physics Physical Chemistry Proton irradiation Radiochemical separation Radioisotopes Rhenium Rhenium isotopes Solvent extraction Sorbents Tungsten |
title | Radiochemical separation of no-carrier-added 186Re from proton irradiated tungsten target |
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