Fabrication of a biodegradable drug delivery system with controlled release made of PLGA 5-FU hydroxyapatite

Purpose - Rapid prototyping (RP) technology has been widely applied in biomedical research. The purpose of this paper is to describe how a scaffold composite drug delivery system (DDS) was fabricated using a nano composite deposition system (NCDS).Design methodology approach - A biocompatible and bi...

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Bibliographic Details
Published in:Rapid prototyping journal 2008-01, Vol.14 (5), p.293-299
Main Authors: Chu, Won-Shik, Jeong, Suk-Young, Kim, Sung-Geun, Ha, Won-Shik, Chi, Sang-Chul, Ahn, Sung-Hoon
Format: Article
Language:English
Subjects:
Additives
Biocompatibility
Biodegradability
Biodegradable materials
Biomedical materials
Biomedical research
Composite materials
Controlled release
Drug delivery systems
Drugs
Electron microscopes
Experiments
Hydroxyapatite
In vitro methods and tests
Performance evaluation
Permeability
Polylactic acid
Polymer matrix composites
Polymers
Pore size
Product development
Rapid prototyping
Scaffolds
Studies
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Summary:Purpose - Rapid prototyping (RP) technology has been widely applied in biomedical research. The purpose of this paper is to describe how a scaffold composite drug delivery system (DDS) was fabricated using a nano composite deposition system (NCDS).Design methodology approach - A biocompatible and biodegradable thermoplastic polymer (poly(DL-lactide-co-glycolide acid)) was used as the matrix, and a mixture of anti-cancer drug (5-fluorouracil) and bio-ceramic (hydroxyapatite - HA) was added to the polymer to form a bio-composite material for the DDS. An in vitro drug release test showed that the release rate of the drug composite could be controlled by the amount of HA for 50 days.Findings - Faster release was observed for the DDS with higher weight percent of HA. The relationship between release rate and the amount of HA showed a bi-linear manner, and bi-linear drug release models were developed based on the experimental results.Originality value - Cylindrical scaffolds were fabricated with polymer drug additive using an NCDS. A series of in vitro drug release tests was performed to evaluate the effectiveness of the additive, HA. Drug release models were developed based on the experimental results.
ISSN:1355-2546
1758-7670
DOI:10.1108/13552540810907965