Investigation of antiplasmodial efficacy of lupeol and ursolic acid isolated from Ficus benjamina leaves extract

This study emphasizes on the investigation of antiplasmodial activity of triterpenoids isolated from Ficus benjamina leaves. An unsaponified fraction of petroleum ether extract of plant leaves was subjected to silica gel column chromatography which led to the isolation of two known triterpenoids; na...

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Bibliographic Details
Published in:Natural product research 2020-09, Vol.34 (17), p.2514-2517
Main Authors: Singh, Amandeep, Mukhtar, Hayat Mohammad, Kaur, Hardeep, Kaur, Lakhvir
Format: Article
Language:English
Subjects:
Acids
Antimalarials - isolation & purification
Antimalarials - pharmacology
antiplasmodial activity
Antiprotozoal agents
Antiprotozoal Agents - isolation & purification
Antiprotozoal Agents - pharmacology
Column chromatography
Ficus - chemistry
Ficus benjamina
Leaves
lupeol
Malaria
Malaria - drug therapy
Pentacyclic Triterpenes - isolation & purification
Pentacyclic Triterpenes - pharmacology
Petroleum ether
Plant extracts
Plant Extracts - chemistry
Plant Leaves - chemistry
Plants
Plasmodium falciparum - drug effects
Silica
Silica gel
Silicon dioxide
Triterpenes - isolation & purification
Triterpenes - pharmacology
Triterpenoids
Ursolic Acid
Vector-borne diseases
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Summary:This study emphasizes on the investigation of antiplasmodial activity of triterpenoids isolated from Ficus benjamina leaves. An unsaponified fraction of petroleum ether extract of plant leaves was subjected to silica gel column chromatography which led to the isolation of two known triterpenoids; namely ursolic acid and lupeol. These compounds were evaluated for antiplasmodial activity by schizont maturation inhibition assay using 3D7 Plasmodium strains. Both, ursolic acid and lupeol were found to exhibit significant antiplasmodial effect with an IC 50 value of 18 µg/ml and 3.8 µg/ml, respectively. This study further confirms the traditional role of Ficus benjamina plant in the treatment of malaria which may be attributed to ursolic acid and lupeol.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2018.1540476